Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts

Aimy Sebastian; Nicholas R. Hum; Deepa K. Murugesh; Sarah Hatsell; Aris N. Economides; Gabriela G. Loots

doi:10.1371/journal.pone.0188264

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Open Access

Peer-reviewed

Research Article

Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts

Aimy Sebastian,

Roles Conceptualization, Formal analysis, Methodology, Writing – original draft

Affiliations Lawrence Livermore National Laboratories, Physical and Life Sciences Directorate, Livermore, CA, United States of America, UC Merced, School of Natural Sciences, Merced, CA, United States of America
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Nicholas R. Hum,

Roles Methodology, Validation

Affiliations Lawrence Livermore National Laboratories, Physical and Life Sciences Directorate, Livermore, CA, United States of America, UC Merced, School of Natural Sciences, Merced, CA, United States of America
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Deepa K. Murugesh,

Roles Investigation, Methodology

Affiliation Lawrence Livermore National Laboratories, Physical and Life Sciences Directorate, Livermore, CA, United States of America
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Sarah Hatsell,

Roles Methodology, Resources

Affiliation Regeneron Pharmaceuticals, Tarrytown, NY, United States of America
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Aris N. Economides,

Roles Methodology, Resources

Affiliation Regeneron Pharmaceuticals, Tarrytown, NY, United States of America
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Gabriela G. Loots

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Resources, Writing – original draft, Writing – review & editing

* E-mail: Loots1@llnl.gov

Affiliations Lawrence Livermore National Laboratories, Physical and Life Sciences Directorate, Livermore, CA, United States of America, UC Merced, School of Natural Sciences, Merced, CA, United States of America

http://orcid.org/0000-0001-9546-5561

⨯

Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts

Aimy Sebastian,
Nicholas R. Hum,
Deepa K. Murugesh,
Sarah Hatsell,
Aris N. Economides,
Gabriela G. Loots

Published: November 27, 2017
https://doi.org/10.1371/journal.pone.0188264

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Osteoblasts
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Gene expression
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Wnt signaling cascade
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Osteoblast differentiation
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Gene regulation
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Bone development
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MAPK signaling cascades
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Gene targeting
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