Why patients with THBD c.1611C>A (p.Cys537X) nonsense mutation have high levels of soluble thrombomodulin?

Yohann Jourdy; Nathalie Enjolras; Sandra Le Quellec; Jean Claude Bordet; Claude Négrier; Christine Vinciguerra; Yesim Dargaud

doi:10.1371/journal.pone.0188213

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Open Access

Peer-reviewed

Research Article

Why patients with THBD c.1611C>A (p.Cys537X) nonsense mutation have high levels of soluble thrombomodulin?

Yohann Jourdy ,

Roles Conceptualization, Investigation, Validation, Writing – original draft

* E-mail: yohann.jourdy@chu-lyon.fr

Affiliations Hospices Civils de Lyon, Centre de Biologie et Pathologies Est, Service d’hématologie Biologique, Bron, France, EAM 4609 Hémostase et cancer, Université Claude Bernard, France

http://orcid.org/0000-0001-7408-6474

⨯
Nathalie Enjolras,

Roles Conceptualization, Investigation, Writing – review & editing

Affiliation EAM 4609 Hémostase et cancer, Université Claude Bernard, France
⨯
Sandra Le Quellec,

Roles Investigation

Affiliations Hospices Civils de Lyon, Centre de Biologie et Pathologies Est, Service d’hématologie Biologique, Bron, France, EAM 4609 Hémostase et cancer, Université Claude Bernard, France, Hospices Civils de Lyon, Hôpital Cardiologique Louis Pradel, Unité d'Hémostase Clinique, Bron, France
⨯
Jean Claude Bordet,

Roles Investigation, Methodology

Affiliations Hospices Civils de Lyon, Centre de Biologie et Pathologies Est, Service d’hématologie Biologique, Bron, France, EAM 4609 Hémostase et cancer, Université Claude Bernard, France
⨯
Claude Négrier,

Roles Writing – review & editing

Affiliations Hospices Civils de Lyon, Centre de Biologie et Pathologies Est, Service d’hématologie Biologique, Bron, France, EAM 4609 Hémostase et cancer, Université Claude Bernard, France, Hospices Civils de Lyon, Hôpital Cardiologique Louis Pradel, Unité d'Hémostase Clinique, Bron, France
⨯
Christine Vinciguerra,

Roles Supervision, Writing – review & editing

Affiliations Hospices Civils de Lyon, Centre de Biologie et Pathologies Est, Service d’hématologie Biologique, Bron, France, EAM 4609 Hémostase et cancer, Université Claude Bernard, France
⨯
Yesim Dargaud

Roles Conceptualization, Investigation, Methodology, Supervision, Validation, Writing – review & editing

Affiliations Hospices Civils de Lyon, Centre de Biologie et Pathologies Est, Service d’hématologie Biologique, Bron, France, EAM 4609 Hémostase et cancer, Université Claude Bernard, France, Hospices Civils de Lyon, Hôpital Cardiologique Louis Pradel, Unité d'Hémostase Clinique, Bron, France
⨯

Why patients with THBD c.1611C>A (p.Cys537X) nonsense mutation have high levels of soluble thrombomodulin?

Yohann Jourdy,
Nathalie Enjolras,
Sandra Le Quellec,
Jean Claude Bordet,
Claude Négrier,
Christine Vinciguerra,
Yesim Dargaud

Published: November 16, 2017
https://doi.org/10.1371/journal.pone.0188213

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Nonsense mutation
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