CD4+ levels control the odds of induction of humoral immune responses to tracer doses of therapeutic antibodies

• Sharat Srinivasula ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: srinivasulas@mail.nih.gov

  Affiliation Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., NCI Campus at Frederick, Frederick, Maryland, United States of America

  http://orcid.org/0000-0003-1867-5762

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• Erin Gabriel,

  Roles Data curation, Formal analysis, Funding acquisition, Methodology, Software, Visualization, Writing – review & editing

  Affiliation Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., NCI Campus at Frederick, Frederick, Maryland, United States of America

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• Insook Kim,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Writing – review & editing

  Affiliation Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., NCI Campus at Frederick, Frederick, Maryland, United States of America

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• Paula DeGrange,

  Roles Investigation, Writing – review & editing

  Affiliation Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland, United States of America

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• Alexis St Claire,

  Roles Investigation, Writing – review & editing

  Affiliation Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Candace Mallow,

  Roles Investigation, Writing – review & editing

  Affiliation Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Robert E. Donahue,

  Roles Funding acquisition, Investigation, Writing – review & editing

  Affiliation Hematology Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Chang Paik,

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

  Affiliation Radiopharmaceutical Laboratory, Nuclear Medicine, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland, United States of America

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• H. C. Lane,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Michele Di Mascio

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

  Affiliation Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America

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