Human pancreatic islet-derived extracellular vesicles modulate insulin expression in 3D-differentiating iPSC clusters

Diana Ribeiro; Eva-Marie Andersson; Nikki Heath; Anette Persson-kry; Richard Collins; Ryan Hicks; Niek Dekker; Anna Forslöw

doi:10.1371/journal.pone.0187665

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Open Access

Peer-reviewed

Research Article

Human pancreatic islet-derived extracellular vesicles modulate insulin expression in 3D-differentiating iPSC clusters

Diana Ribeiro ,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

* E-mail: diana.ribeiro@astrazeneca.com (DR); anna.forslow@astrazeneca.com (AF)

Affiliations Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden, Department of Biology and Bioengineering, Chalmers University of Technology, Gothenburg, Sweden

http://orcid.org/0000-0001-7829-6305

⨯
Eva-Marie Andersson,

Roles Investigation, Writing – review & editing

Affiliation Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯
Nikki Heath,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Alderley Park, Macclesfield, United Kingdom
⨯
Anette Persson-kry,

Roles Investigation

Affiliation Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯
Richard Collins,

Roles Investigation

Affiliation Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
⨯
Ryan Hicks,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliation Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯
Niek Dekker,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯
Anna Forslöw

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: diana.ribeiro@astrazeneca.com (DR); anna.forslow@astrazeneca.com (AF)

Affiliation Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden
⨯

Human pancreatic islet-derived extracellular vesicles modulate insulin expression in 3D-differentiating iPSC clusters

Diana Ribeiro,
Eva-Marie Andersson,
Nikki Heath,
Anette Persson-kry,
Richard Collins,
Ryan Hicks,
Niek Dekker,
Anna Forslöw

Published: November 8, 2017
https://doi.org/10.1371/journal.pone.0187665

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