Assessing single-stranded oligonucleotide drug-induced effects in vitro reveals key risk factors for thrombocytopenia

• Sabine Sewing ,

  Contributed equally to this work with: Sabine Sewing, Adrian B. Roth

  Roles Conceptualization, Formal analysis, Investigation, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: sabine.sewing@roche.com

  Affiliation Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland

  http://orcid.org/0000-0003-0547-3977

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• Adrian B. Roth ,

  Contributed equally to this work with: Sabine Sewing, Adrian B. Roth

  Roles Conceptualization, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland

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• Michael Winter,

  Roles Conceptualization, Formal analysis, Investigation, Resources, Validation, Visualization, Writing – review & editing

  Affiliation Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland

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• Andreas Dieckmann,

  Roles Conceptualization, Resources, Writing – original draft, Writing – review & editing

  Affiliation Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland

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• Cristina Bertinetti-Lapatki,

  Roles Conceptualization, Formal analysis, Investigation, Resources, Validation, Visualization, Writing – original draft

  Affiliation Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland

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• Yann Tessier,

  Roles Conceptualization, Writing – original draft, Writing – review & editing

  Affiliation Roche Pharma Research and Early Development, Roche Innovation Center Copenhagen A/S, Hørsholm, Denmark

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• Claudia McGinnis,

  Roles Formal analysis, Investigation, Resources, Validation, Visualization, Writing – original draft

  Affiliation Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland

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• Sylwia Huber,

  Roles Formal analysis, Investigation, Resources, Validation

  Affiliation Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland

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• Erich Koller,

  Roles Conceptualization, Writing – original draft

  Affiliation Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland

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• Corinne Ploix,

  Roles Formal analysis, Investigation, Resources, Validation, Visualization, Writing – original draft

  Affiliation Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland

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• John C. Reed,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland

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• Thomas Singer,

  Roles Conceptualization, Supervision

  Affiliation Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland

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• Andreas Rothfuss

  Roles Conceptualization, Project administration, Supervision, Writing – original draft

  Affiliation Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland

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