Apoptosis signal-regulating kinase 1 inhibition attenuates cardiac hypertrophy and cardiorenal fibrosis induced by uremic toxins: Implications for cardiorenal syndrome

Feby Savira; Longxing Cao; Ian Wang; Wendi Yang; Kevin Huang; Yue Hua; Beat M. Jucker; Robert N. Willette; Li Huang; Henry Krum; Zhiliang Li; Qiang Fu; Bing Hui Wang

doi:10.1371/journal.pone.0187459

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Open Access

Peer-reviewed

Research Article

Apoptosis signal-regulating kinase 1 inhibition attenuates cardiac hypertrophy and cardiorenal fibrosis induced by uremic toxins: Implications for cardiorenal syndrome

Feby Savira ,

Contributed equally to this work with: Feby Savira, Longxing Cao

Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
⨯
Longxing Cao ,

Contributed equally to this work with: Feby Savira, Longxing Cao

Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia, Zhujiang Hospital, School of Medicine, Southern Medical University, Guangzhou, China
⨯
Ian Wang,

Roles Data curation, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
⨯
Wendi Yang,

Roles Data curation, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
⨯
Kevin Huang,

Roles Data curation, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
⨯
Yue Hua,

Roles Data curation, Formal analysis, Writing – original draft, Writing – review & editing

Affiliations Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
⨯
Beat M. Jucker,

Roles Writing – original draft, Writing – review & editing

Affiliation Heart Failure Discovery Performance Unit, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
⨯
Robert N. Willette,

Roles Writing – original draft, Writing – review & editing

Affiliation Heart Failure Discovery Performance Unit, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
⨯
Li Huang,

Roles Data curation, Formal analysis, Writing – original draft

Affiliation Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
⨯
Henry Krum,

Roles Conceptualization, Funding acquisition, Investigation, Resources, Supervision

Affiliation Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
⨯
Zhiliang Li,

Roles Funding acquisition, Resources, Software, Supervision, Writing – original draft

Affiliation Zhujiang Hospital, School of Medicine, Southern Medical University, Guangzhou, China
⨯
Qiang Fu,

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia, Zhujiang Hospital, School of Medicine, Southern Medical University, Guangzhou, China
⨯
Bing Hui Wang

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: bing.wang@monash.edu

Affiliation Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia

http://orcid.org/0000-0001-9580-2548

⨯

Apoptosis signal-regulating kinase 1 inhibition attenuates cardiac hypertrophy and cardiorenal fibrosis induced by uremic toxins: Implications for cardiorenal syndrome

Feby Savira,
Longxing Cao,
Ian Wang,
Wendi Yang,
Kevin Huang,
Yue Hua,
Beat M. Jucker,
Robert N. Willette,
Li Huang,
Henry Krum

Published: November 6, 2017
https://doi.org/10.1371/journal.pone.0187459

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