Porcine brain extract promotes osteogenic differentiation of bone marrow derived mesenchymal stem cells and bone consolidation in a rat distraction osteogenesis model

• Jia Xu ,

  Contributed equally to this work with: Jia Xu, Yuxin Sun

  Roles Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

  ⨯
• Yuxin Sun ,

  Contributed equally to this work with: Jia Xu, Yuxin Sun

  Roles Data curation, Methodology, Writing – original draft

  Affiliation Department of Orthopaedics & Traumatology, Stem Cells and Regeneration Laboratory, Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China

  ⨯
• Tianyi Wu,

  Roles Methodology, Software

  Affiliation Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

  ⨯
• Bin Wang,

  Roles Data curation, Methodology

  Affiliation Department of Orthopaedics & Traumatology, Stem Cells and Regeneration Laboratory, Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China

  ⨯
• Yang Liu,

  Roles Data curation, Methodology

  Affiliation Department of Orthopaedics & Traumatology, Stem Cells and Regeneration Laboratory, Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China

  ⨯
• Jinfang Zhang,

  Roles Project administration, Supervision

  Affiliations Department of Orthopaedics & Traumatology, Stem Cells and Regeneration Laboratory, Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China, The CUHK-ACC Space Medicine Centre, The Chinese University of Hong Kong Shenzhen Research Institute, Shenzhen, China

  ⨯
• Wayne Yukwai Lee,

  Roles Conceptualization, Investigation, Project administration

  Affiliation Department of Orthopaedics & Traumatology, Stem Cells and Regeneration Laboratory, Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China

  ⨯
• Qinglin Kang,

  Roles Investigation, Supervision

  Affiliation Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

  ⨯
• Yimin Chai ,

  Roles Funding acquisition, Writing – review & editing

  * E-mail: gangli@cuhk.edu.hk (GL); ymchai@sjtu.edu.cn (YC)

  Affiliation Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

  ⨯
• Gang Li

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  * E-mail: gangli@cuhk.edu.hk (GL); ymchai@sjtu.edu.cn (YC)

  Affiliations Department of Orthopaedics & Traumatology, Stem Cells and Regeneration Laboratory, Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China, The CUHK-ACC Space Medicine Centre, The Chinese University of Hong Kong Shenzhen Research Institute, Shenzhen, China

  ⨯