HLA-DRB1 and DQB1 alleles in Japanese type 1 autoimmune hepatitis: The predisposing role of the DR4/DR8 heterozygous genotype

• Shomi Oka,

  Roles Formal analysis, Investigation, Writing – original draft

  Affiliations Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Japan, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, 18–1 Sakuradai, Minami-ku, Sagamihara, Japan

  ⨯
• Hiroshi Furukawa ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – review & editing

  * E-mail: furukawa-tky@umin.org

  Affiliations Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Japan, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, 18–1 Sakuradai, Minami-ku, Sagamihara, Japan

  http://orcid.org/0000-0003-1353-8056

  ⨯
• Michio Yasunami,

  Roles Conceptualization, Funding acquisition, Investigation, Supervision

  Affiliations Department of Medical Genomics, Life Science Institute, Saga-ken Medical Centre Koseikan, 400 Kasemachi-Nakabaru, Saga, Japan, Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Japan

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• Aya Kawasaki,

  Roles Conceptualization, Writing – review & editing

  Affiliation Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Japan

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• Hitomi Nakamura,

  Roles Investigation

  Affiliation Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Japan

  ⨯
• Minoru Nakamura,

  Roles Resources

  Affiliations Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki, Japan, Clinical Research Center, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Japan, NHO-AIH study group, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Japan

  ⨯
• Atsumasa Komori,

  Roles Resources

  Affiliations Clinical Research Center, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Japan, NHO-AIH study group, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Japan

  ⨯
• Seigo Abiru,

  Roles Resources

  Affiliation NHO-AIH study group, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Japan

  ⨯
• Shinya Nagaoka,

  Roles Resources

  Affiliation NHO-AIH study group, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Japan

  ⨯
• Satoru Hashimoto,

  Roles Resources

  Affiliation NHO-AIH study group, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Japan

  ⨯
• Atsushi Naganuma,

  Roles Resources

  Affiliation NHO-AIH study group, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Japan

  ⨯
• Noriaki Naeshiro,

  Roles Resources

  Affiliation NHO-AIH study group, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Japan

  ⨯
• Kaname Yoshizawa,

  Roles Resources

  Affiliation NHO-AIH study group, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Japan

  ⨯
• Haruhiro Yamashita,

  Roles Resources

  Affiliation NHO-AIH study group, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Japan

  ⨯
• Keisuke Ario,

  Roles Resources

  Affiliation NHO-AIH study group, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Japan

  ⨯
• Hajime Ohta,

  Roles Resources

  Affiliation NHO-AIH study group, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Japan

  ⨯
• Hironori Sakai,

  Roles Resources

  Affiliation NHO-AIH study group, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Japan

  ⨯
• Iwao Yabuuchi,

  Roles Resources

  Affiliation NHO-AIH study group, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Japan

  ⨯
• Atsushi Takahashi,

  Roles Conceptualization

  Affiliation Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Japan

  ⨯
• Kazumichi Abe,

  Roles Conceptualization

  Affiliation Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Japan

  ⨯
• Hiroshi Yatsuhashi,

  Roles Resources

  Affiliations Clinical Research Center, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Japan, NHO-AIH study group, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Japan

  ⨯
• Shigeto Tohma,

  Roles Resources

  Affiliation Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, 18–1 Sakuradai, Minami-ku, Sagamihara, Japan

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• Hiromasa Ohira,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Japan

  ⨯
• Naoyuki Tsuchiya ,

  Contributed equally to this work with: Naoyuki Tsuchiya, Kiyoshi Migita

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Japan

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•  [ ... ],
• Kiyoshi Migita

  Contributed equally to this work with: Naoyuki Tsuchiya, Kiyoshi Migita

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  Affiliations Clinical Research Center, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Japan, NHO-AIH study group, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Japan, Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Japan

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