Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states

Andrea S. Heimann; Achla Gupta; Ivone Gomes; Rahman Rayees; Avner Schlessinger; Emer S. Ferro; Ellen M. Unterwald; Lakshmi A. Devi

doi:10.1371/journal.pone.0187306

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Open Access

Peer-reviewed

Research Article

Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states

Andrea S. Heimann ,

Contributed equally to this work with: Andrea S. Heimann, Achla Gupta, Ivone Gomes

Roles Conceptualization, Investigation, Validation, Writing – original draft

* E-mail: lakshmi.devi@mssm.edu (LAD); andrea@proteimaxnet.com.br (ASH)

Affiliation Proteimax Biotechnology LTDA, Av Corifeu de Azevedo Marques, São Paulo, SP, Brazil
⨯
Achla Gupta ,

Contributed equally to this work with: Andrea S. Heimann, Achla Gupta, Ivone Gomes

Roles Investigation, Validation

Affiliation Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, United States of America
⨯
Ivone Gomes ,

Contributed equally to this work with: Andrea S. Heimann, Achla Gupta, Ivone Gomes

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, United States of America
⨯
Rahman Rayees,

Roles Investigation

Affiliation Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, United States of America
⨯
Avner Schlessinger,

Roles Conceptualization, Investigation

Affiliation Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, United States of America
⨯
Emer S. Ferro,

Roles Conceptualization, Writing – review & editing

Affiliation Department of Pharmacology, Biomedical Science Institute, University of São Paulo, São Paulo, SP, Brazil
⨯
Ellen M. Unterwald,

Roles Investigation, Resources

Affiliation Department of Pharmacology, Temple University School of Medicine, Philadelphia, United States of America
⨯
Lakshmi A. Devi

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: lakshmi.devi@mssm.edu (LAD); andrea@proteimaxnet.com.br (ASH)

Affiliation Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, United States of America

http://orcid.org/0000-0002-2179-2874

⨯

Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states

Andrea S. Heimann,
Achla Gupta,
Ivone Gomes,
Rahman Rayees,
Avner Schlessinger,
Emer S. Ferro,
Ellen M. Unterwald,
Lakshmi A. Devi

Published: November 1, 2017
https://doi.org/10.1371/journal.pone.0187306

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Immunohistochemistry techniques
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Pattern recognition receptors
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Antibodies
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G protein coupled receptors
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