Pofut1 point-mutations that disrupt O-fucosyltransferase activity destabilize the protein and abolish Notch1 signaling during mouse somitogenesis

• Rieko Ajima ,

  Roles Conceptualization, Investigation, Writing – original draft

  * E-mail: rajima@nig.ac.jp (RA); ysaga@nig.ac.jp (YS)

  Affiliations Mammalian Development Laboratory, Genetic Strains Research Center, National Institute of Genetics, Mishima, Shizuoka, Japan, Mouse Research Supporting Unit, National Institute of Genetics, Mishima, Shizuoka, Japan, Department of Genetics, SOKENDAI, Mishima, Shizuoka, Japan

  http://orcid.org/0000-0001-9740-2660

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• Emiko Suzuki,

  Roles Investigation

  Affiliations Department of Genetics, SOKENDAI, Mishima, Shizuoka, Japan, Gene Network Laboratory, Structural Biology Center, National Institute of Genetics, Mishima, Shizuoka, Japan

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• Yumiko Saga

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: rajima@nig.ac.jp (RA); ysaga@nig.ac.jp (YS)

  Affiliations Mammalian Development Laboratory, Genetic Strains Research Center, National Institute of Genetics, Mishima, Shizuoka, Japan, Mouse Research Supporting Unit, National Institute of Genetics, Mishima, Shizuoka, Japan, Department of Genetics, SOKENDAI, Mishima, Shizuoka, Japan, Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

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