Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner

• Josephe A. Honorat ,

  Contributed equally to this work with: Josephe A. Honorat, Yuji Nakatsuji, Mikito Shimizu

  Roles Conceptualization, Formal analysis, Investigation, Project administration, Writing – original draft

  Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  ⨯
• Yuji Nakatsuji ,

  Contributed equally to this work with: Josephe A. Honorat, Yuji Nakatsuji, Mikito Shimizu

  Roles Conceptualization, Formal analysis, Project administration

  * E-mail: okuno@neurol.med.osaka-u.ac.jp (TO); nakatsuj@med.u-toyama.ac.jp (YN)

  Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  ⨯
• Mikito Shimizu ,

  Contributed equally to this work with: Josephe A. Honorat, Yuji Nakatsuji, Mikito Shimizu

  Roles Formal analysis, Investigation

  Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  ⨯
• Makoto Kinoshita,

  Roles Project administration

  Affiliation Department of Neurology, Osaka General Medical Center, Osaka, Osaka, Japan

  ⨯
• Hisae Sumi-Akamaru,

  Roles Formal analysis, Investigation

  Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  ⨯
• Tsutomu Sasaki,

  Roles Project administration

  Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  ⨯
• Kazushiro Takata,

  Roles Project administration

  Affiliation Department of Neurology, Osaka General Medical Center, Osaka, Osaka, Japan

  ⨯
• Toru Koda,

  Roles Project administration

  Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  ⨯
• Akiko Namba,

  Roles Formal analysis

  Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  ⨯
• Kazuya Yamashita,

  Roles Formal analysis

  Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  ⨯
• Eri Sanda,

  Roles Formal analysis, Investigation

  Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  ⨯
• Manabu Sakaguchi,

  Roles Formal analysis, Investigation

  Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  ⨯
• Atsushi Kumanogoh,

  Roles Formal analysis

  Affiliation Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  ⨯
• Takashi Shirakura,

  Roles Project administration

  Affiliation Pharmaceutical Development Research Laboratories, Teijin Pharma Ltd., Hino, Tokyo, Japan

  ⨯
• Mizuho Tamura,

  Roles Project administration

  Affiliation Pharmaceutical Development Research Laboratories, Teijin Pharma Ltd., Hino, Tokyo, Japan

  ⨯
• Saburo Sakoda,

  Roles Project administration

  Affiliation Department of Neurology, National Hospital Organization Toneyama National Hospital, Toyonaka, Osaka, Japan

  ⨯
• Hideki Mochizuki,

  Roles Project administration

  Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  ⨯
•  [ ... ],
• Tatsusada Okuno

  Roles Conceptualization, Formal analysis, Investigation, Project administration

  * E-mail: okuno@neurol.med.osaka-u.ac.jp (TO); nakatsuj@med.u-toyama.ac.jp (YN)

  Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  http://orcid.org/0000-0001-6173-3759

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