Essential roles of aspartate aminotransferase 1 and vesicular glutamate transporters in β-cell glutamate signaling for incretin-induced insulin secretion

• Naoya Murao,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan

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• Norihide Yokoi ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: yokoi@med.kobe-u.ac.jp (NY); seino@med.kobe-u.ac.jp (SS)

  Affiliation Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan

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• Kohei Honda,

  Roles Investigation, Writing – review & editing

  Affiliation Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan

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• Guirong Han,

  Roles Investigation, Writing – review & editing

  Affiliations Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan, Kansai Electric Power Medical Research Institute, Kobe, Japan, Division of Medical Chemistry, Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan

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• Tomohide Hayami,

  Roles Investigation, Writing – review & editing

  Affiliations Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan, Kansai Electric Power Medical Research Institute, Kobe, Japan, Division of Diabetes, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan

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• Ghupurjan Gheni,

  Roles Investigation, Writing – review & editing

  Affiliation Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan

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• Harumi Takahashi,

  Roles Writing – review & editing

  Affiliation Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan

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• Kohtaro Minami,

  Roles Investigation, Writing – review & editing

  Affiliation Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan

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• Susumu Seino

  Roles Funding acquisition, Supervision, Writing – review & editing

  * E-mail: yokoi@med.kobe-u.ac.jp (NY); seino@med.kobe-u.ac.jp (SS)

  Affiliation Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan

  http://orcid.org/0000-0002-5596-9754

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