Establishment of a novel hepatocyte model that expresses four cytochrome P450 genes stably via mammalian-derived artificial chromosome for pharmacokinetics and toxicity studies

• Daisuke Satoh,

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  Affiliation Chromosome Engineering Research Center, Tottori University, Tottori, Japan

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• Satoru Iwado,

  Roles Data curation, Formal analysis, Methodology

  Affiliation Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University, Tottori, Japan

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• Satoshi Abe,

  Roles Conceptualization, Data curation, Formal analysis, Writing – review & editing

  Affiliation Chromosome Engineering Research Center, Tottori University, Tottori, Japan

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• Kanako Kazuki,

  Roles Resources

  Affiliation Chromosome Engineering Research Center, Tottori University, Tottori, Japan

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• Shinobu Wakuri,

  Roles Data curation, Formal analysis, Methodology, Project administration, Writing – review & editing

  Affiliation Food and Drug Safety Center, Tokyo, Japan

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• Mitsuo Oshimura,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Writing – review & editing

  Affiliation Chromosome Engineering Research Center, Tottori University, Tottori, Japan

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• Yasuhiro Kazuki

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Writing – review & editing

  * E-mail: kazuki@grape.med.tottori-u.ac.jp

  Affiliations Chromosome Engineering Research Center, Tottori University, Tottori, Japan, Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University, Tottori, Japan

  http://orcid.org/0000-0003-4818-4710

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