Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia

Lijie Ma; Yan Liu; Nichole K. Landry; Tarek M. El-Achkar; John C. Lieske; Xue-Ru Wu

doi:10.1371/journal.pone.0186769

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Peer-reviewed

Research Article

Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia

Lijie Ma ,

Contributed equally to this work with: Lijie Ma, Yan Liu

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation Departments of Urology and Pathology, New York University School of Medicine, New York, New York, United States of America
⨯
Yan Liu ,

Contributed equally to this work with: Lijie Ma, Yan Liu

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Departments of Urology and Pathology, New York University School of Medicine, New York, New York, United States of America
⨯
Nichole K. Landry,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation Division of Nephrology, Indiana University School of Medicine and Indianapolis VA, Indianapolis, Indiana, United States of America
⨯
Tarek M. El-Achkar,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – review & editing

Affiliation Division of Nephrology, Indiana University School of Medicine and Indianapolis VA, Indianapolis, Indiana, United States of America
⨯
John C. Lieske,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – review & editing

Affiliation Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Xue-Ru Wu

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: xue-ru.wu@med.nyu.edu

Affiliations Departments of Urology and Pathology, New York University School of Medicine, New York, New York, United States of America, Veterans Affairs New York Harbor Healthcare System, Manhattan Campus, New York, New York, United States of America

http://orcid.org/0000-0001-6058-6291

⨯

Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia

Lijie Ma,
Yan Liu,
Nichole K. Landry,
Tarek M. El-Achkar,
John C. Lieske,
Xue-Ru Wu

Published: November 16, 2017
https://doi.org/10.1371/journal.pone.0186769

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