Antioxidants and NOX1/NOX4 inhibition blocks TGFβ1-induced CCN2 and α-SMA expression in dermal and gingival fibroblasts

Hannah Murphy-Marshman; Katherine Quensel; Xu Shi-wen; Rebecca Barnfield; Jacalyn Kelly; Alex Peidl; Richard J. Stratton; Andrew Leask

doi:10.1371/journal.pone.0186740

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Open Access

Peer-reviewed

Research Article

Antioxidants and NOX1/NOX4 inhibition blocks TGFβ1-induced CCN2 and α-SMA expression in dermal and gingival fibroblasts

Hannah Murphy-Marshman,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Dentistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
⨯
Katherine Quensel,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Supervision, Writing – review & editing

Affiliation Department of Dentistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
⨯
Xu Shi-wen,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Centre for Rheumatology, Royal Free and University College Medical School, London, United Kingdom
⨯
Rebecca Barnfield,

Roles Data curation, Formal analysis, Investigation

Affiliation Department of Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
⨯
Jacalyn Kelly,

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
⨯
Alex Peidl,

Roles Data curation, Formal analysis, Investigation

Affiliation Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
⨯
Richard J. Stratton,

Roles Conceptualization, Resources, Supervision

Affiliation Centre for Rheumatology, Royal Free and University College Medical School, London, United Kingdom
⨯
Andrew Leask

Roles Conceptualization, Funding acquisition, Supervision, Visualization

* E-mail: Andrew.Leask@schulich.uwo.ca

Affiliations Department of Dentistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada, Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada

http://orcid.org/0000-0003-2832-283X

⨯

Antioxidants and NOX1/NOX4 inhibition blocks TGFβ1-induced CCN2 and α-SMA expression in dermal and gingival fibroblasts

Hannah Murphy-Marshman,
Katherine Quensel,
Xu Shi-wen,
Rebecca Barnfield,
Jacalyn Kelly,
Alex Peidl,
Richard J. Stratton,
Andrew Leask

Published: October 19, 2017
https://doi.org/10.1371/journal.pone.0186740

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Antioxidants
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