Characterization of the first knock-out aldh7a1 zebrafish model for pyridoxine-dependent epilepsy using CRISPR-Cas9 technology

• Nikita Zabinyakov,

  Roles Data curation, Writing – review & editing

  Affiliation Genetics and Genome Biology Program, Research Institute, The Hospital for Sick Children, Toronto, Canada

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• Garrett Bullivant,

  Roles Data curation, Visualization, Writing – review & editing

  Affiliation Division of Clinical and Metabolic Genetics, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada

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• Feng Cao,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliations Neurosciences and Mental Health Program, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Physiology, University of Toronto, Toronto, Canada

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• Matilde Fernandez Ojeda,

  Roles Data curation, Writing – review & editing

  Affiliation Metabolic Laboratory, Department of Clinical Chemistry, VU University Medical Center, Amsterdam, Neuroscience Amsterdam, The Netherlands

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• Zheng Ping Jia,

  Roles Data curation, Writing – review & editing

  Affiliations Neurosciences and Mental Health Program, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Physiology, University of Toronto, Toronto, Canada

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• Xiao-Yan Wen,

  Roles Data curation, Writing – review & editing

  Affiliation Zebrafish Centre for Advanced Drug Discovery & Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada

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• James J. Dowling,

  Roles Data curation, Writing – review & editing

  Affiliations Genetics and Genome Biology Program, Research Institute, The Hospital for Sick Children, Toronto, Canada, Division of Neurology, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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• Gajja S. Salomons,

  Roles Data curation, Writing – review & editing

  Affiliations Metabolic Laboratory, Department of Clinical Chemistry, VU University Medical Center, Amsterdam, Neuroscience Amsterdam, The Netherlands, Neuroscience Campus, Amsterdam, The Netherlands

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• Saadet Mercimek-Andrews

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: saadet.andrews@sickkids.ca

  Affiliations Genetics and Genome Biology Program, Research Institute, The Hospital for Sick Children, Toronto, Canada, Division of Clinical and Metabolic Genetics, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada, Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada

  http://orcid.org/0000-0001-8396-6764

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