Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy

Akira Shibata; Masako Kuno; Ryutaro Adachi; Yosuke Sato; Harumi Hattori; Atsushi Matsuda; Yuumi Okuzono; Keiko Igaki; Yusuke Tominari; Terufumi Takagi; Masato Yabuki; Masanori Okaniwa

doi:10.1371/journal.pone.0186587

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Open Access

Peer-reviewed

Research Article

Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy

Akira Shibata ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: bata.176518@gmail.com (AS); masanori.okaniwa@takeda.com (MO)

Affiliation Immunology Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

http://orcid.org/0000-0001-9458-813X

⨯
Masako Kuno,

Roles Investigation, Methodology, Validation

Affiliation Immunology Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Ryutaro Adachi,

Roles Formal analysis, Investigation, Validation, Writing – original draft

Affiliation Biomolecular Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Yosuke Sato,

Roles Investigation, Validation

Affiliation Immunology Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Harumi Hattori,

Roles Investigation, Validation

Affiliation Immunology Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Atsushi Matsuda,

Roles Investigation, Validation

Affiliation Immunology Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Yuumi Okuzono,

Roles Data curation, Formal analysis, Software

Affiliation Immunology Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Keiko Igaki,

Roles Investigation, Validation

Affiliation Immunology Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Yusuke Tominari,

Roles Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Immunology Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Terufumi Takagi,

Roles Formal analysis, Methodology, Visualization, Writing – original draft

Affiliation Medicinal Chemistry Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Masato Yabuki,

Roles Project administration, Writing – original draft, Writing – review & editing

Affiliation Immunology Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Masanori Okaniwa

Roles Conceptualization, Formal analysis, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: bata.176518@gmail.com (AS); masanori.okaniwa@takeda.com (MO)

Affiliation Immunology Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯

Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy

Akira Shibata,
Masako Kuno,
Ryutaro Adachi,
Yosuke Sato,
Harumi Hattori,
Atsushi Matsuda,
Yuumi Okuzono,
Keiko Igaki,
Yusuke Tominari,
Terufumi Takagi

Published: October 24, 2017
https://doi.org/10.1371/journal.pone.0186587

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