Enrichment of colorectal cancer associations in functional regions: Insight for using epigenomics data in the analysis of whole genome sequence-imputed GWAS data

• Stephanie A. Bien ,

  Contributed equally to this work with: Stephanie A. Bien, Paul L. Auer, Tabitha A. Harrison

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: lih@fredhutch.org (LH); sbien@fredhutch.org (SAB)

  Affiliation Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  http://orcid.org/0000-0002-8713-4583

  ⨯
• Paul L. Auer ,

  Contributed equally to this work with: Stephanie A. Bien, Paul L. Auer, Tabitha A. Harrison

  Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Joseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, United States of America

  ⨯
• Tabitha A. Harrison ,

  Contributed equally to this work with: Stephanie A. Bien, Paul L. Auer, Tabitha A. Harrison

  Roles Conceptualization, Project administration, Writing – review & editing

  Affiliation Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  http://orcid.org/0000-0002-4173-7530

  ⨯
• Conghui Qu,

  Roles Formal analysis, Writing – original draft

  Affiliation Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  ⨯
• Charles M. Connolly,

  Roles Data curation

  Affiliation Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  http://orcid.org/0000-0002-3297-8586

  ⨯
• Peyton G. Greenside,

  Roles Visualization

  Affiliation Biomedical Informatics Program, Stanford University, Stanford, California, United States of America

  ⨯
• Sai Chen,

  Roles Formal analysis

  Affiliation Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Sonja I. Berndt,

  Roles Data curation, Writing – review & editing

  Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Stéphane Bézieau,

  Roles Data curation, Writing – review & editing

  Affiliation Service de Génétique Médicale, Centre Hospitalier Universitaire de Nantes, Nantes, France

  ⨯
• Hyun M. Kang,

  Roles Supervision

  Affiliation Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Jeroen Huyghe,

  Roles Investigation

  Affiliation Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  ⨯
• Hermann Brenner,

  Roles Data curation, Writing – review & editing

  Affiliations Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany, Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany

  ⨯
• Graham Casey,

  Roles Data curation

  Affiliation Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America

  ⨯
• Andrew T. Chan,

  Roles Data curation

  Affiliations Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• John L. Hopper,

  Roles Data curation

  Affiliation Centre for Epidemiology and Biostatistics, Melbourne School of Population Health, The University of Melbourne, Melbourne, Victoria, Australia

  http://orcid.org/0000-0002-8567-173X

  ⨯
• Barbara L. Banbury,

  Roles Writing – review & editing

  Affiliation Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  ⨯
• Jenny Chang-Claude,

  Roles Data curation, Writing – review & editing

  Affiliations Division of Cancer Epidemiology C020, German Cancer Research Center (DKFZ), Heidelberg, Germany, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  ⨯
• Stephen J. Chanock,

  Roles Data curation, Writing – review & editing

  Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Robert W. Haile,

  Roles Data curation, Writing – review & editing

  Affiliation Division of Medical Oncology, Stanford School of Medicine, Stanford, California, United States of America

  http://orcid.org/0000-0003-4271-8371

  ⨯
• Michael Hoffmeister,

  Roles Data curation, Writing – review & editing

  Affiliation Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany

  ⨯
• Christian Fuchsberger,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Mark A. Jenkins,

  Roles Data curation, Writing – review & editing

  Affiliation Centre for Epidemiology and Biostatistics, Melbourne School of Population Health, The University of Melbourne, Melbourne, Victoria, Australia

  http://orcid.org/0000-0002-8964-6160

  ⨯
• Suzanne M. Leal,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine Center for Statistical Genetics, Houston, Texas, United States of America

  ⨯
• Mathieu Lemire,

  Roles Data curation, Writing – review & editing

  Affiliation Ontario Institute for Cancer Research, MaRS Centre, South Tower, Toronto, Ontario, Canada

  ⨯
• Polly A. Newcomb,

  Roles Data curation

  Affiliation Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  ⨯
• Steven Gallinger,

  Roles Data curation

  Affiliation Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, Canada

  ⨯
• John D. Potter,

  Roles Data curation

  Affiliation Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  ⨯
• Robert E. Schoen,

  Roles Data curation

  Affiliation Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America

  http://orcid.org/0000-0001-7153-2766

  ⨯
• Martha L. Slattery,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America

  ⨯
• Joshua D. Smith,

  Roles Data curation

  Affiliation Department Genome Sciences, University of Washington, Seattle, Washington, United States of America

  ⨯
• Loic Le Marchand,

  Roles Data curation

  Affiliation University of Hawai’i Cancer Center, Honolulu, Hawai’i, United States of America

  ⨯
• Emily White,

  Roles Data curation, Writing – review & editing

  Affiliations Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

  ⨯
• Brent W. Zanke,

  Roles Data curation, Writing – review & editing

  Affiliations Division of Hematology, University of Ottawa, Ottawa, Ontario, Canada, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

  ⨯
• Goncalo R. Abeçasis,

  Roles Resources, Software

  Affiliation Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Christopher S. Carlson,

  Roles Supervision

  Affiliations Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

  http://orcid.org/0000-0003-0561-3538

  ⨯
• Ulrike Peters,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliations Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

  ⨯
• Deborah A. Nickerson,

  Roles Conceptualization, Writing – review & editing

  Affiliation Department Genome Sciences, University of Washington, Seattle, Washington, United States of America

  ⨯
• Anshul Kundaje ,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Resources, Supervision, Writing – review & editing

  ¶‡ These authors also contributed equally to this work.

  Affiliation Department of Genetics, Stanford University, Stanford, California, United States of America

  http://orcid.org/0000-0003-3084-2287

  ⨯
• Li Hsu ,

  Roles Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: lih@fredhutch.org (LH); sbien@fredhutch.org (SAB)

  ¶‡ These authors also contributed equally to this work.

  Affiliations Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

  ⨯
•  [ ... ],
• on behalf of GECCO and CCFR

  ¶Membership of the GECCO and CCFR Consortia are provided in the Acknowledgments.

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