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Open Access

Peer-reviewed

Research Article

Cordycepin promotes apoptosis in renal carcinoma cells by activating the MKK7-JNK signaling pathway through inhibition of c-FLIP_L expression

In-Hu Hwang ,

Contributed equally to this work with: In-Hu Hwang, Seung Yoon Oh

Roles Formal analysis, Writing – original draft

Affiliations Department of Physiology, Korea University College of Medicine, Seoul, Republic of Korea, Neuroscience Research Institute, Korea University College of Medicine, Seoul, Republic of Korea
⨯
Seung Yoon Oh ,

Contributed equally to this work with: In-Hu Hwang, Seung Yoon Oh

Roles Formal analysis

Affiliation Department of Sasang Constitutional Medicine, Wonkwang University, Iksan, Republic of Korea
⨯
Hyun-Jin Jang,

Roles Data curation, Methodology

Affiliation Division of Bioconvergence Analysis, Korea Basic Science Institute, Daejeon, Republic of Korea
⨯
Eunbi Jo,

Roles Validation, Writing – review & editing

Affiliation Division of Bioconvergence Analysis, Korea Basic Science Institute, Daejeon, Republic of Korea
⨯
Jong Cheon Joo,

Roles Data curation, Methodology

Affiliation Department of Sasang Constitutional Medicine, Wonkwang University, Iksan, Republic of Korea
⨯
Kyung-Bok Lee,

Roles Data curation, Formal analysis, Methodology

Affiliation Division of Bioconvergence Analysis, Korea Basic Science Institute, Daejeon, Republic of Korea
⨯
Hwa-Seung Yoo,

Roles Data curation, Validation

Affiliation East-West Cancer Center, Daejeon University, Daejeon, Korea
⨯
Mi Young Lee,

Roles Data curation, Validation

Affiliation KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Korea
⨯
Soo Jung Park,

Roles Funding acquisition, Resources

Affiliation Department of Sasang Constitutional Medicine, Woosuk University, Wanju, Jeonbuk, Republic of Korea
⨯
Ik-Soon Jang

Roles Conceptualization, Funding acquisition, Writing – review & editing

* E-mail: jangiksn@kbsi.re.kr

Affiliation Division of Bioconvergence Analysis, Korea Basic Science Institute, Daejeon, Republic of Korea

http://orcid.org/0000-0003-2092-6372

⨯

Cordycepin promotes apoptosis in renal carcinoma cells by activating the MKK7-JNK signaling pathway through inhibition of c-FLIP_L expression

In-Hu Hwang,
Seung Yoon Oh,
Hyun-Jin Jang,
Eunbi Jo,
Jong Cheon Joo,
Kyung-Bok Lee,
Hwa-Seung Yoo,
Mi Young Lee,
Soo Jung Park,
Ik-Soon Jang

x

Published: October 18, 2017
https://doi.org/10.1371/journal.pone.0186489

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Transcription factors
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Renal cancer
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Apoptosis
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Cancer treatment
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Signal inhibition
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Protein kinase signaling cascade
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Cancers and neoplasms
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Inflammation
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