ER stress and subsequent activated calpain play a pivotal role in skeletal muscle wasting after severe burn injury

Li Ma; Wanli Chu; Jiake Chai; Chuanan Shen; Dawei Li; Xiaoteng Wang

doi:10.1371/journal.pone.0186128

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Open Access

Peer-reviewed

Research Article

ER stress and subsequent activated calpain play a pivotal role in skeletal muscle wasting after severe burn injury

Li Ma ,

Contributed equally to this work with: Li Ma, Wanli Chu

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

Affiliation Department of Burn & Plastic Surgery, Burns Institute, First Hospital affiliated to General Hospital of the Chinese People's Liberation Army, Beijing, China
⨯
Wanli Chu ,

Contributed equally to this work with: Li Ma, Wanli Chu

Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

Affiliation Department of Burn & Plastic Surgery, Burns Institute, First Hospital affiliated to General Hospital of the Chinese People's Liberation Army, Beijing, China
⨯
Jiake Chai ,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: cjk304@126.com

Affiliation Department of Burn & Plastic Surgery, Burns Institute, First Hospital affiliated to General Hospital of the Chinese People's Liberation Army, Beijing, China

http://orcid.org/0000-0002-3858-6137

⨯
Chuanan Shen,

Roles Supervision, Writing – original draft, Writing – review & editing

Affiliation Department of Burn & Plastic Surgery, Burns Institute, First Hospital affiliated to General Hospital of the Chinese People's Liberation Army, Beijing, China
⨯
Dawei Li,

Roles Formal analysis, Methodology, Project administration, Software, Validation, Visualization

Affiliation Department of Burn & Plastic Surgery, Burns Institute, First Hospital affiliated to General Hospital of the Chinese People's Liberation Army, Beijing, China
⨯
Xiaoteng Wang

Roles Data curation, Software, Validation, Visualization

Affiliation Department of Burn & Plastic Surgery, Burns Institute, First Hospital affiliated to General Hospital of the Chinese People's Liberation Army, Beijing, China
⨯

ER stress and subsequent activated calpain play a pivotal role in skeletal muscle wasting after severe burn injury

Li Ma,
Wanli Chu,
Jiake Chai,
Chuanan Shen,
Dawei Li,
Xiaoteng Wang

Published: October 13, 2017
https://doi.org/10.1371/journal.pone.0186128

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Skeletal muscles
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Burns
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Musculoskeletal injury
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Endoplasmic reticulum
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Autophagic cell death
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Myofibrils
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Body weight
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Muscle proteins
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