A novel controller based on state-transition models for closed-loop vagus nerve stimulation: Application to heart rate regulation

• Hector M. Romero-Ugalde,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations INSERM, U1099, Rennes, F-35000, France, Université de Rennes 1, LTSI, Rennes, F-35000, France

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• Virginie Le Rolle ,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: virginie.lerolle@univ-rennes1.fr

  Affiliations INSERM, U1099, Rennes, F-35000, France, Université de Rennes 1, LTSI, Rennes, F-35000, France

  http://orcid.org/0000-0003-1068-5587

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• Jean-Luc Bonnet,

  Roles Investigation, Writing – review & editing

  Affiliation Sorin CRM SAS (a LivaNova company), Clamart, France

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• Christine Henry,

  Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Sorin CRM SAS (a LivaNova company), Clamart, France

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• Alain Bel,

  Roles Investigation, Resources

  Affiliation INSERM, UMR970 Paris Cardio-vascular Research Center, Paris, France, Assistance Publique-Hôpitaux de Paris, Department of Cardiology, Hôpital Européen Georges Pompidou, Paris, France, Paris Descartes University, PRES Paris Sorbonne, Paris, France

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• Philippe Mabo,

  Roles Supervision

  Affiliations INSERM, U1099, Rennes, F-35000, France, Université de Rennes 1, LTSI, Rennes, F-35000, France, CHU Rennes, Department of Cardiology and INSERM, CIC-IT 1414, Rennes, F-35000, France

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• Guy Carrault,

  Roles Funding acquisition, Supervision

  Affiliations INSERM, U1099, Rennes, F-35000, France, Université de Rennes 1, LTSI, Rennes, F-35000, France

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• Alfredo I. Hernández

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations INSERM, U1099, Rennes, F-35000, France, Université de Rennes 1, LTSI, Rennes, F-35000, France

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