The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling

Inna Gordiienko; Larysa Shlapatska; Valeriia Kholodniuk; Lilia Sklyarenko; Daniel F. Gluzman; Edward A. Clark; Svetlana P. Sidorenko

doi:10.1371/journal.pone.0185940

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Open Access

Peer-reviewed

Research Article

The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling

Inna Gordiienko,

Roles Conceptualization, Investigation, Methodology, Writing – original draft

Affiliation Department of Molecular and Cellular Pathobiology, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine, Kyiv, Ukraine
⨯
Larysa Shlapatska,

Roles Formal analysis, Investigation

Affiliation Department of Molecular and Cellular Pathobiology, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine, Kyiv, Ukraine
⨯
Valeriia Kholodniuk,

Roles Investigation

Affiliation Department of Molecular and Cellular Pathobiology, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine, Kyiv, Ukraine
⨯
Lilia Sklyarenko,

Roles Resources, Validation

Affiliation Department of Oncohematology, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine, Kyiv, Ukraine
⨯
Daniel F. Gluzman,

Roles Resources, Supervision

Affiliation Department of Oncohematology, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine, Kyiv, Ukraine
⨯
Edward A. Clark,

Roles Funding acquisition, Resources, Writing – review & editing

Affiliation Department of Immunology, University of Washington, Seattle, Washington, United States of America
⨯
Svetlana P. Sidorenko

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: svitasyd@yahoo.com

Affiliation Department of Molecular and Cellular Pathobiology, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine, Kyiv, Ukraine

http://orcid.org/0000-0001-8281-8006

⨯

The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling

Inna Gordiienko,
Larysa Shlapatska,
Valeriia Kholodniuk,
Lilia Sklyarenko,
Daniel F. Gluzman,
Edward A. Clark,
Svetlana P. Sidorenko

Published: October 5, 2017
https://doi.org/10.1371/journal.pone.0185940

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B cells
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B cell receptors
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MAPK signaling cascades
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Phosphorylation
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Chronic lymphoblastic leukemia
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Gene expression
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Hematologic cancers and related disorders
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Neoplastic transformation
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