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Open Access
Peer-reviewed
Research Article
Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors
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Mark Merchant ,
Contributed equally to this work with: Mark Merchant, John Moffat
Roles Conceptualization, Data curation, Formal analysis, Supervision, Visualization, Writing – original draft, Writing – review & editing
Affiliation Department of Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America
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John Moffat ,
Contributed equally to this work with: Mark Merchant, John Moffat
Roles Conceptualization, Formal analysis, Visualization, Writing – review & editing
Affiliation Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California, United States of America
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Gabriele Schaefer,
Roles Investigation, Supervision, Writing – review & editing
Affiliation Department of Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America
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Jocelyn Chan,
Roles Investigation
Affiliation Department of Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America
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Xi Wang,
Roles Investigation
Affiliation Department of Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America
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Christine Orr,
Roles Investigation
Affiliation Department of Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America
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Jason Cheng,
Roles Investigation, Supervision, Visualization
Affiliation Department of Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America
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Thomas Hunsaker,
Roles Investigation
Affiliation Department of Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America
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Lily Shao,
Roles Investigation, Visualization
Affiliation Department of Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America
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Stephanie J. Wang,
Roles Data curation, Methodology
Affiliation Department of Biological Engineering, The Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
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Marie-Claire Wagle,
Roles Investigation
Affiliation Department of Oncology Biomarker Development, Genentech, Inc., South San Francisco, California, United States of America
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Eva Lin,
Roles Investigation, Software
Affiliation Department of Discovery Oncology, Genentech, Inc., South San Francisco, California, United States of America
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Peter M. Haverty,
Roles Investigation, Methodology
Affiliation Department of Bioinformatics, Genentech, Inc., South San Francisco, California, United States of America
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Sheerin Shahidi-Latham,
Roles Supervision
Affiliation Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, United States of America
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Hai Ngu,
Roles Investigation
Affiliation Department of Pathology, Genentech, Inc., South San Francisco, California, United States of America
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Margaret Solon,
Roles Investigation
Affiliation Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California, United States of America
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Jeffrey Eastham-Anderson,
Roles Investigation
Affiliation Department of Pathology, Genentech, Inc., South San Francisco, California, United States of America
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Hartmut Koeppen,
Roles Project administration, Resources, Supervision
Affiliation Department of Pathology, Genentech, Inc., South San Francisco, California, United States of America
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Shih-Min A. Huang,
Roles Conceptualization, Supervision
Affiliation Department of Oncology Biomarker Development, Genentech, Inc., South San Francisco, California, United States of America
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Jacob Schwarz,
Roles Investigation
Affiliation Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California, United States of America
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Marcia Belvin,
Roles Supervision
Affiliation Department of Cancer Immunology, Genentech, Inc., South San Francisco, California, United States of America
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Daniel Kirouac,
Roles Software, Visualization, Writing – review & editing
Affiliation Department of Pre-clinical & Translational Pharmacokinetics Genentech, Inc., South San Francisco, California, United States of America
⨯ - [ ... ],
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Melissa R. Junttila
Roles Conceptualization, Formal analysis, Investigation, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing
* E-mail: junttila.melissa@gene.com
Affiliation Department of Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America
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Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors
- Mark Merchant,
- John Moffat,
- Gabriele Schaefer,
- Jocelyn Chan,
- Xi Wang,
- Christine Orr,
- Jason Cheng,
- Thomas Hunsaker,
- Lily Shao,
- Stephanie J. Wang
![PLOS](/resource/img/logo-plos.png)
- Published: October 5, 2017
- https://doi.org/10.1371/journal.pone.0185862