Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors

• Mark Merchant ,

  Contributed equally to this work with: Mark Merchant, John Moffat

  Roles Conceptualization, Data curation, Formal analysis, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America

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• John Moffat ,

  Contributed equally to this work with: Mark Merchant, John Moffat

  Roles Conceptualization, Formal analysis, Visualization, Writing – review & editing

  Affiliation Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California, United States of America

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• Gabriele Schaefer,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliation Department of Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America

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• Jocelyn Chan,

  Roles Investigation

  Affiliation Department of Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America

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• Xi Wang,

  Roles Investigation

  Affiliation Department of Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America

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• Christine Orr,

  Roles Investigation

  Affiliation Department of Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America

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• Jason Cheng,

  Roles Investigation, Supervision, Visualization

  Affiliation Department of Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America

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• Thomas Hunsaker,

  Roles Investigation

  Affiliation Department of Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America

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• Lily Shao,

  Roles Investigation, Visualization

  Affiliation Department of Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America

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• Stephanie J. Wang,

  Roles Data curation, Methodology

  Affiliation Department of Biological Engineering, The Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Marie-Claire Wagle,

  Roles Investigation

  Affiliation Department of Oncology Biomarker Development, Genentech, Inc., South San Francisco, California, United States of America

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• Eva Lin,

  Roles Investigation, Software

  Affiliation Department of Discovery Oncology, Genentech, Inc., South San Francisco, California, United States of America

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• Peter M. Haverty,

  Roles Investigation, Methodology

  Affiliation Department of Bioinformatics, Genentech, Inc., South San Francisco, California, United States of America

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• Sheerin Shahidi-Latham,

  Roles Supervision

  Affiliation Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, United States of America

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• Hai Ngu,

  Roles Investigation

  Affiliation Department of Pathology, Genentech, Inc., South San Francisco, California, United States of America

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• Margaret Solon,

  Roles Investigation

  Affiliation Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California, United States of America

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• Jeffrey Eastham-Anderson,

  Roles Investigation

  Affiliation Department of Pathology, Genentech, Inc., South San Francisco, California, United States of America

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• Hartmut Koeppen,

  Roles Project administration, Resources, Supervision

  Affiliation Department of Pathology, Genentech, Inc., South San Francisco, California, United States of America

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• Shih-Min A. Huang,

  Roles Conceptualization, Supervision

  Affiliation Department of Oncology Biomarker Development, Genentech, Inc., South San Francisco, California, United States of America

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• Jacob Schwarz,

  Roles Investigation

  Affiliation Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California, United States of America

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• Marcia Belvin,

  Roles Supervision

  Affiliation Department of Cancer Immunology, Genentech, Inc., South San Francisco, California, United States of America

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• Daniel Kirouac,

  Roles Software, Visualization, Writing – review & editing

  Affiliation Department of Pre-clinical & Translational Pharmacokinetics Genentech, Inc., South San Francisco, California, United States of America

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•  [ ... ],
• Melissa R. Junttila

  Roles Conceptualization, Formal analysis, Investigation, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: junttila.melissa@gene.com

  Affiliation Department of Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America

  http://orcid.org/0000-0003-3538-1192

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