Vaccine adjuvant MF59 promotes the intranodal differentiation of antigen-loaded and activated monocyte-derived dendritic cells

Rossella Cioncada; Marcella Maddaluno; Hoa Thi My Vo; Matthew Woodruff; Simona Tavarini; Chiara Sammicheli; Marco Tortoli; Alfredo Pezzicoli; Ennio De Gregorio; Michael C. Carroll; Ugo D’Oro; Diego Piccioli

doi:10.1371/journal.pone.0185843

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Open Access

Peer-reviewed

Research Article

Vaccine adjuvant MF59 promotes the intranodal differentiation of antigen-loaded and activated monocyte-derived dendritic cells

Rossella Cioncada,

Roles Data curation, Formal analysis, Investigation, Methodology

Current address: University of Brescia, Spedali Civili, Brescia, Italy

Affiliation GSK Vaccines, Siena, Italy
⨯
Marcella Maddaluno,

Roles Data curation, Formal analysis

Current address: Kedrion Biopharma, Bolognana, Lucca, Italy

Affiliation GSK Vaccines, Siena, Italy
⨯
Hoa Thi My Vo,

Roles Data curation, Formal analysis

Affiliation GSK Vaccines, Siena, Italy
⨯
Matthew Woodruff,

Roles Data curation, Formal analysis, Investigation

Current address: Emory University, Atlanta, GA, United States of America

Affiliation Boston Children’s Hospital, Harvard Medical School, Boston, MA, United States of America
⨯
Simona Tavarini,

Roles Data curation, Formal analysis

Affiliation GSK Vaccines, Siena, Italy
⨯
Chiara Sammicheli,

Roles Data curation, Formal analysis

Affiliation GSK Vaccines, Siena, Italy
⨯
Marco Tortoli,

Roles Investigation

Affiliation GSK Vaccines, Siena, Italy
⨯
Alfredo Pezzicoli,

Roles Data curation, Formal analysis

Affiliation GSK Vaccines, Siena, Italy
⨯
Ennio De Gregorio,

Roles Funding acquisition, Resources

Affiliation GSK Vaccines, Siena, Italy
⨯
Michael C. Carroll,

Roles Resources, Supervision

Affiliation Boston Children’s Hospital, Harvard Medical School, Boston, MA, United States of America
⨯
Ugo D’Oro ,

Roles Project administration, Resources, Supervision, Writing – review & editing

* E-mail: diego.x.piccioli@gmail.com (DP); ugo.x.doro@gsk.com (UDO)

Affiliation GSK Vaccines, Siena, Italy
⨯
Diego Piccioli

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: diego.x.piccioli@gmail.com (DP); ugo.x.doro@gsk.com (UDO)

Affiliation GSK Vaccines, Siena, Italy

http://orcid.org/0000-0002-5809-4455

⨯

Vaccine adjuvant MF59 promotes the intranodal differentiation of antigen-loaded and activated monocyte-derived dendritic cells

Rossella Cioncada,
Marcella Maddaluno,
Hoa Thi My Vo,
Matthew Woodruff,
Simona Tavarini,
Chiara Sammicheli,
Marco Tortoli,
Alfredo Pezzicoli,
Ennio De Gregorio,
Michael C. Carroll

Published: October 31, 2017
https://doi.org/10.1371/journal.pone.0185843

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Antigen-presenting cells
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Immunologic adjuvants
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Flow cytometry
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Monocytes
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Cell differentiation
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