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A small molecule drug promoting miRNA processing induces alternative splicing of MdmX transcript and rescues p53 activity in human cancer cells overexpressing MdmX protein
- Georgios Valianatos ,
- Barbora Valcikova ,
- Katerina Growkova,
- Amandine Verlande,
- Jitka Mlcochova,
- Lenka Radova,
- Monika Stetkova,
- Michaela Vyhnakova,
- Ondrej Slaby,
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Stjepan Uldrijan
Roles Conceptualization, Funding acquisition, Investigation, Project administration, Writing – original draft, Writing – review & editing
* E-mail: uldrijan@med.muni.cz
Affiliations Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic, International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic
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http://orcid.org/0000-0001-8316-2539
A small molecule drug promoting miRNA processing induces alternative splicing of MdmX transcript and rescues p53 activity in human cancer cells overexpressing MdmX protein
- Georgios Valianatos,
- Barbora Valcikova,
- Katerina Growkova,
- Amandine Verlande,
- Jitka Mlcochova,
- Lenka Radova,
- Monika Stetkova,
- Michaela Vyhnakova,
- Ondrej Slaby,
- Stjepan Uldrijan
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- Published: October 3, 2017
- https://doi.org/10.1371/journal.pone.0185801