Pleiotropy of genetic variants on obesity and smoking phenotypes: Results from the Oncoarray Project of The International Lung Cancer Consortium

Tao Wang; Jee-Young Moon; Yiqun Wu; Christopher I. Amos; Rayjean J. Hung; Adonina Tardon; Angeline Andrew; Chu Chen; David C. Christiani; Demetrios Albanes; Erik H. F. M. van der Heijden; Eric Duell; Gadi Rennert; Gary Goodman; Geoffrey Liu; James D. Mckay; Jian-Min Yuan; John K. Field; Jonas Manjer; Kjell Grankvist; Lambertus A. Kiemeney; Loic Le Marchand; M. Dawn Teare; Matthew B. Schabath; Mattias Johansson; Melinda C. Aldrich; Michael Davies; Mikael Johansson; Ming-Sound Tsao; Neil Caporaso; Philip Lazarus; Stephen Lam; Stig E. Bojesen; Susanne Arnold; Xifeng Wu; Xuchen Zong; Yun-Chul Hong; Gloria Y. F. Ho

doi:10.1371/journal.pone.0185660

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Open Access

Peer-reviewed

Research Article

Pleiotropy of genetic variants on obesity and smoking phenotypes: Results from the Oncoarray Project of The International Lung Cancer Consortium

Tao Wang ,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

* E-mail: tao.wang@einstein.yu.edu (TW); gho1@northwell.edu (GYFH)

Affiliation Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Jee-Young Moon,

Roles Formal analysis, Methodology

Affiliation Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America

http://orcid.org/0000-0001-9218-8335

⨯
Yiqun Wu,

Roles Formal analysis, Writing – review & editing

Affiliations Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Epidemiology & Biostatistics, School of public health, Peking University Health Science Center, Beijing, China

http://orcid.org/0000-0002-5554-1678

⨯
Christopher I. Amos,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, United States of America
⨯
Rayjean J. Hung,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Lunenfeld-Tanenbaum Research Institute, Sinai Health System; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada

http://orcid.org/0000-0002-4486-7496

⨯
Adonina Tardon,

Roles Data curation, Investigation, Writing – review & editing

Affiliation IUOPA. University of Oviedo and CIBERESP. Oviedo, Spain
⨯
Angeline Andrew,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Norris Cotton Cancer Center, Hanover, New Hampshire, United States of America
⨯
Chu Chen,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
David C. Christiani,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Harvard School of Public Health, Boston, Massachusetts, United States of America

http://orcid.org/0000-0002-0301-0242

⨯
Demetrios Albanes,

Roles Data curation, Investigation, Writing – review & editing

Affiliation National Cancer Institute, Bethesda, United States of America
⨯
Erik H. F. M. van der Heijden,

Roles Data curation, Investigation

Affiliation Radboud university medical center, Nijmegen, Netherlands

http://orcid.org/0000-0003-3596-518X

⨯
Eric Duell,

Roles Data curation, Investigation

Affiliation Catalan Institute of Oncology (ICO), Barcelona, Spain
⨯
Gadi Rennert,

Roles Data curation, Investigation

Affiliation Carmel Medical Center, Haifa, Israel
⨯
Gary Goodman,

Roles Data curation, Investigation

Affiliation Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Geoffrey Liu,

Roles Data curation, Investigation

Affiliation Lunenfeld-Tanenbaum Research Institute, Sinai Health System; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
⨯
James D. Mckay,

Roles Data curation, Investigation

Affiliation International Agency for Research on Cancer (IARC), Lyon, France
⨯
Jian-Min Yuan,

Roles Data curation, Investigation

Affiliation University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America
⨯
John K. Field,

Roles Data curation, Investigation

Affiliation Roy Castle Lung Cancer Research Programme, Department of Molecular & Clinical Cancer Medicine, The University of Liverpool, Liverpool, UK

http://orcid.org/0000-0003-3951-6365

⨯
Jonas Manjer,

Roles Data curation, Investigation

Affiliation Department of surgery, Unit for breast surgery, Lund University, Malmö, Skåne University Hospital Malmö, Malmö, Sweden
⨯
Kjell Grankvist,

Roles Data curation, Investigation

Affiliation Department of Medical Biosciences, Umeå University, Umeå, Sweden
⨯
Lambertus A. Kiemeney,

Roles Data curation, Investigation

Affiliation Radboud university medical center, Nijmegen, Netherlands

http://orcid.org/0000-0002-2368-1326

⨯
Loic Le Marchand,

Roles Data curation, Investigation

Affiliation University of Hawaii Cancer Center, Honolulu, Hawai'I, United States of America
⨯
M. Dawn Teare,

Roles Data curation, Investigation

Affiliation University Of Sheffield, Sheffield, South Yorkshire, United Kingdom
⨯
Matthew B. Schabath,

Roles Data curation, Investigation

Affiliation Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America

http://orcid.org/0000-0003-3241-3216

⨯
Mattias Johansson,

Roles Data curation, Investigation

Affiliation International Agency for Research on Cancer (IARC), Lyon, France
⨯
Melinda C. Aldrich,

Roles Data curation, Investigation

Affiliation Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
⨯
Michael Davies,

Roles Data curation, Investigation

Affiliation Roy Castle Lung Cancer Research Programme, Department of Molecular & Clinical Cancer Medicine, The University of Liverpool, Liverpool, UK
⨯
Mikael Johansson,

Roles Data curation, Investigation

Affiliation Department of Medical Biosciences, Umeå University, Umeå, Sweden
⨯
Ming-Sound Tsao,

Roles Data curation, Investigation

Affiliation Princess Margaret Cancer Center, Toronto, Ontario, Canada
⨯
Neil Caporaso,

Roles Data curation, Investigation

Affiliation National Cancer Institute, Bethesda, United States of America
⨯
Philip Lazarus,

Roles Data curation, Investigation

Affiliation Washington State University College of Pharmacy, Washington, United States of America
⨯
Stephen Lam,

Roles Data curation, Investigation

Affiliation British Columbia Cancer Agency, Vancouver, British Columbia, Canada
⨯
Stig E. Bojesen,

Roles Data curation, Investigation

Affiliations Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen, Denmark, Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Susanne Arnold,

Roles Data curation, Investigation

Affiliation Markey Cancer Center, Lexington, Kentucky, United States of America

http://orcid.org/0000-0001-6542-9551

⨯
Xifeng Wu,

Roles Data curation, Investigation

Affiliation The University of Texas MD Anderson Cancer Center, Texas, Houston, United States of America
⨯
Xuchen Zong,

Roles Data curation, Investigation

Affiliation Lunenfeld-Tanenbaum Research Institute, Sinai Health System; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
⨯
Yun-Chul Hong,

Roles Conceptualization, Investigation

Affiliation Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
⨯
[ ... ],
Gloria Y. F. Ho

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

* E-mail: tao.wang@einstein.yu.edu (TW); gho1@northwell.edu (GYFH)

Affiliations Merinoff Center for Patient-Oriented Research, The Feinstein Institute for Medical Research, New York, United States of America, Epidemiology and Research, Northwell Health, New York, United States of America, Hofstra Northwell School of Medicine, New York, United States of America
⨯
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Pleiotropy of genetic variants on obesity and smoking phenotypes: Results from the Oncoarray Project of The International Lung Cancer Consortium

Tao Wang,
Jee-Young Moon,
Yiqun Wu,
Christopher I. Amos,
Rayjean J. Hung,
Adonina Tardon,
Angeline Andrew,
Chu Chen,
David C. Christiani,
Demetrios Albanes

Published: September 28, 2017
https://doi.org/10.1371/journal.pone.0185660

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Body mass index
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Single nucleotide polymorphisms
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Obesity
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