Network modeling of kinase inhibitor polypharmacology reveals pathways targeted in chemical screens

• Oana Ursu,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: Dept. of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

  Affiliation Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Sara J. C. Gosline,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Neil Beeharry,

  Roles Data curation, Formal analysis, Investigation, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: LAM Therapeutics, Guilford, Connecticut, United States of America

  Affiliation Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

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• Lauren Fink,

  Roles Investigation, Validation

  Affiliation Cancer Biology Program, Fox Chase Cancer Center; Philadelphia, Pennsylvania, United States of America

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• Vikram Bhattacharjee,

  Roles Data curation, Investigation, Validation

  Affiliation Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

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• Shao-shan Carol Huang,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Validation

  Affiliations Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America, Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California, United States of America

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• Yan Zhou,

  Roles Formal analysis, Software, Validation

  Affiliation Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

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• Tim Yen,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

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• Ernest Fraenkel

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: fraenkel-admin@mit.edu

  Affiliation Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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