Augmentation of VAMP-catalytic activity of botulinum neurotoxin serotype B does not result in increased potency in physiological systems

• Mark Elliott ,

  Contributed equally to this work with: Mark Elliott, Jacquie Maignel, Sai Man Liu, Christine Favre-Guilmard, Shilpa Palan, Matthew Beard, Johannes Krupp

  Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: mark.elliott@ipsen.com

  Affiliation Ipsen Bioinnovation, 102 Park Drive, Milton Park, Abingdon, United Kingdom

  http://orcid.org/0000-0002-5281-7245

  ⨯
• Jacquie Maignel ,

  Contributed equally to this work with: Mark Elliott, Jacquie Maignel, Sai Man Liu, Christine Favre-Guilmard, Shilpa Palan, Matthew Beard, Johannes Krupp

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Ipsen Innovation, Les Ulis, France

  ⨯
• Sai Man Liu ,

  Contributed equally to this work with: Mark Elliott, Jacquie Maignel, Sai Man Liu, Christine Favre-Guilmard, Shilpa Palan, Matthew Beard, Johannes Krupp

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Ipsen Bioinnovation, 102 Park Drive, Milton Park, Abingdon, United Kingdom

  ⨯
• Christine Favre-Guilmard ,

  Contributed equally to this work with: Mark Elliott, Jacquie Maignel, Sai Man Liu, Christine Favre-Guilmard, Shilpa Palan, Matthew Beard, Johannes Krupp

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Ipsen Innovation, Les Ulis, France

  ⨯
• Imran Mir ,

  Roles Formal analysis, Investigation

  ¶‡ These authors also contributed equally to this work.

  Affiliation Ipsen Bioinnovation, 102 Park Drive, Milton Park, Abingdon, United Kingdom

  ⨯
• Paul Farrow ,

  Roles Data curation, Formal analysis, Investigation, Methodology

  ¶‡ These authors also contributed equally to this work.

  Affiliation Ipsen Bioinnovation, 102 Park Drive, Milton Park, Abingdon, United Kingdom

  ⨯
• Fraser Hornby ,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  ¶‡ These authors also contributed equally to this work.

  Affiliation Ipsen Bioinnovation, 102 Park Drive, Milton Park, Abingdon, United Kingdom

  ⨯
• Sandra Marlin ,

  Roles Investigation

  ¶‡ These authors also contributed equally to this work.

  Affiliation Ipsen Bioinnovation, 102 Park Drive, Milton Park, Abingdon, United Kingdom

  ⨯
• Shilpa Palan ,

  Contributed equally to this work with: Mark Elliott, Jacquie Maignel, Sai Man Liu, Christine Favre-Guilmard, Shilpa Palan, Matthew Beard, Johannes Krupp

  Roles Data curation, Formal analysis, Supervision

  Affiliation Ipsen Bioinnovation, 102 Park Drive, Milton Park, Abingdon, United Kingdom

  ⨯
• Matthew Beard ,

  Contributed equally to this work with: Mark Elliott, Jacquie Maignel, Sai Man Liu, Christine Favre-Guilmard, Shilpa Palan, Matthew Beard, Johannes Krupp

  Roles Conceptualization, Project administration, Writing – review & editing

  Affiliation Ipsen Bioinnovation, 102 Park Drive, Milton Park, Abingdon, United Kingdom

  ⨯
• Johannes Krupp

  Contributed equally to this work with: Mark Elliott, Jacquie Maignel, Sai Man Liu, Christine Favre-Guilmard, Shilpa Palan, Matthew Beard, Johannes Krupp

  Roles Conceptualization, Project administration, Writing – original draft, Writing – review & editing

  Affiliation Ipsen Innovation, Les Ulis, France

  ⨯