Low-intensity pulsed ultrasound enhances angiogenesis and ameliorates contractile dysfunction of pressure-overloaded heart in mice

Tsuyoshi Ogata; Kenta Ito; Tomohiko Shindo; Kazuaki Hatanaka; Kumiko Eguchi; Ryo Kurosawa; Yuta Kagaya; Yuto Monma; Sadamitsu Ichijo; Hirofumi Taki; Hiroshi Kanai; Hiroaki Shimokawa

doi:10.1371/journal.pone.0185555

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Open Access

Peer-reviewed

Research Article

Low-intensity pulsed ultrasound enhances angiogenesis and ameliorates contractile dysfunction of pressure-overloaded heart in mice

Tsuyoshi Ogata,

Roles Investigation

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Kenta Ito ,

Roles Project administration

* E-mail: ito-kenta@cardio.med.tohoku.ac.jp

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Tomohiko Shindo,

Roles Investigation

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Kazuaki Hatanaka,

Roles Investigation

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Kumiko Eguchi,

Roles Investigation

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Ryo Kurosawa,

Roles Investigation

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Yuta Kagaya,

Roles Investigation

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Yuto Monma,

Roles Investigation

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Sadamitsu Ichijo,

Roles Investigation

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Hirofumi Taki,

Roles Methodology

Affiliations Department of Electronic Engineering, Graduate School of Engineering, Tohoku University, Sendai, Japan, Division of Biomedical Measurements and Diagnostics, Graduate School of Biomedical Engineering, Tohoku University, Sendai, Japan
⨯
Hiroshi Kanai,

Roles Project administration

Affiliations Department of Electronic Engineering, Graduate School of Engineering, Tohoku University, Sendai, Japan, Division of Biomedical Measurements and Diagnostics, Graduate School of Biomedical Engineering, Tohoku University, Sendai, Japan
⨯
Hiroaki Shimokawa

Roles Project administration

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯

Low-intensity pulsed ultrasound enhances angiogenesis and ameliorates contractile dysfunction of pressure-overloaded heart in mice

Tsuyoshi Ogata,
Kenta Ito,
Tomohiko Shindo,
Kazuaki Hatanaka,
Kumiko Eguchi,
Ryo Kurosawa,
Yuta Kagaya,
Yuto Monma,
Sadamitsu Ichijo,
Hirofumi Taki

Published: September 28, 2017
https://doi.org/10.1371/journal.pone.0185555

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Heart
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Angiogenesis
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Fibrosis
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Heart failure
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