Presumptive brain influx of large neutral amino acids and the effect of phenylalanine supplementation in patients with Tyrosinemia type 1

• Willem G. van Ginkel ,

  Contributed equally to this work with: Willem G. van Ginkel, Danique van Vliet

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Metabolic Diseases, Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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• Danique van Vliet ,

  Contributed equally to this work with: Willem G. van Ginkel, Danique van Vliet

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Metabolic Diseases, Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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• Johannes G. M. Burgerhof,

  Roles Formal analysis, Methodology, Resources, Writing – review & editing

  Affiliation Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen The Netherlands

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• Pim de Blaauw,

  Roles Resources, Writing – review & editing

  Affiliation Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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• M. Estela Rubio Gozalbo,

  Roles Resources, Writing – review & editing

  Affiliation Department of Pediatrics and Laboratory Genetic Metabolic Diseases, Maastricht University Medical Center, Maastricht, The Netherlands

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• M. Rebecca Heiner-Fokkema,

  Roles Data curation, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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• Francjan J. van Spronsen

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: f.j.van.spronsen@umcg.nl

  Affiliation Department of Metabolic Diseases, Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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