The rare nonsense mutation in p53 triggers alternative splicing to produce a protein capable of inducing apoptosis

Evgeny M. Makarov; Tatyana A. Shtam; Roman A. Kovalev; Rimma A. Pantina; Elena Yu Varfolomeeva; Michael V. Filatov

doi:10.1371/journal.pone.0185126

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Open Access

Peer-reviewed

Research Article

The rare nonsense mutation in p53 triggers alternative splicing to produce a protein capable of inducing apoptosis

Evgeny M. Makarov,

Roles Conceptualization, Data curation, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Division of Biosciences, College of Health and Life Sciences, Brunel University London, Uxbridge, United Kingdom
⨯
Tatyana A. Shtam,

Roles Investigation, Visualization, Writing – original draft

Affiliations National Research Centre "Kurchatov Institute" B.P. Konstantinov Petersburg Nuclear Physics Institute, Gatchina, Russia, Peter the Great St Petersburg Polytechnic University, St Petersburg, Russia, Petrov Institute of Oncology, St Petersburg, Russia
⨯
Roman A. Kovalev,

Roles Investigation, Visualization

Affiliation National Research Centre "Kurchatov Institute" B.P. Konstantinov Petersburg Nuclear Physics Institute, Gatchina, Russia
⨯
Rimma A. Pantina,

Roles Investigation

Affiliation National Research Centre "Kurchatov Institute" B.P. Konstantinov Petersburg Nuclear Physics Institute, Gatchina, Russia
⨯
Elena Yu Varfolomeeva,

Roles Investigation

Affiliation National Research Centre "Kurchatov Institute" B.P. Konstantinov Petersburg Nuclear Physics Institute, Gatchina, Russia
⨯
Michael V. Filatov

Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: fil53ster@gmail.com

Affiliation National Research Centre "Kurchatov Institute" B.P. Konstantinov Petersburg Nuclear Physics Institute, Gatchina, Russia

http://orcid.org/0000-0003-3908-3061

⨯

The rare nonsense mutation in p53 triggers alternative splicing to produce a protein capable of inducing apoptosis

Evgeny M. Makarov,
Tatyana A. Shtam,
Roman A. Kovalev,
Rimma A. Pantina,
Elena Yu Varfolomeeva,
Michael V. Filatov

Published: September 29, 2017
https://doi.org/10.1371/journal.pone.0185126

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Transfection
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Nonsense mutation
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Mutation databases
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Point mutation
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DNA-binding proteins
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Apoptosis
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Colorectal cancer
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Restriction fragment length polymorphism analysis
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