Conjugated nanoliposome with the HER2/neu-derived peptide GP2 as an effective vaccine against breast cancer in mice xenograft model

Atefeh Razazan; Javad Behravan; Atefeh Arab; Nastaran Barati; Leila Arabi; Zahra Gholizadeh; Mahdi Hatamipour; Amin Reza Nikpoor; Amir Abbas Momtazi-Borojeni; Fatemeh Mosaffa; Mohamad Hosein Ghahremani; Mahmoud Reza Jaafari

doi:10.1371/journal.pone.0185099

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Peer-reviewed

Research Article

Conjugated nanoliposome with the HER2/neu-derived peptide GP2 as an effective vaccine against breast cancer in mice xenograft model

Atefeh Razazan,

Roles Data curation, Formal analysis, Investigation, Software, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran Iran, Nanotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
⨯
Javad Behravan,

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Visualization, Writing – review & editing

Affiliations Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
⨯
Atefeh Arab,

Roles Investigation, Software, Writing – review & editing

Affiliations Nanotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
⨯
Nastaran Barati,

Roles Investigation, Writing – review & editing

Affiliations Nanotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
⨯
Leila Arabi,

Roles Investigation, Writing – review & editing

Affiliations Nanotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
⨯
Zahra Gholizadeh,

Roles Formal analysis, Investigation, Supervision, Writing – review & editing

Affiliation Department of Immunology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
⨯
Mahdi Hatamipour,

Roles Data curation, Software, Writing – review & editing

Affiliations Nanotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
⨯
Amin Reza Nikpoor,

Roles Investigation, Software, Supervision, Writing – review & editing

Affiliation Department of Immunology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
⨯
Amir Abbas Momtazi-Borojeni,

Roles Data curation, Software, Writing – review & editing

Affiliations Nanotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, Student Research Committee, Department of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
⨯
Fatemeh Mosaffa,

Roles Software, Writing – review & editing

Affiliations Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
⨯
Mohamad Hosein Ghahremani ,

Roles Funding acquisition, Investigation, Resources, Writing – review & editing

* E-mail: JafariMR@mums.ac.ir (MRJ); mhghahremani@sina.tums.ac.ir (MHG)

Affiliation Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran Iran
⨯
Mahmoud Reza Jaafari

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: JafariMR@mums.ac.ir (MRJ); mhghahremani@sina.tums.ac.ir (MHG)

Affiliations Nanotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
⨯

Conjugated nanoliposome with the HER2/neu-derived peptide GP2 as an effective vaccine against breast cancer in mice xenograft model

Atefeh Razazan,
Javad Behravan,
Atefeh Arab,
Nastaran Barati,
Leila Arabi,
Zahra Gholizadeh,
Mahdi Hatamipour,
Amin Reza Nikpoor,
Amir Abbas Momtazi-Borojeni,
Fatemeh Mosaffa

Published: October 18, 2017
https://doi.org/10.1371/journal.pone.0185099

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Liposomes
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