Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform

• A. Theron,

  Roles Data curation, Investigation, Writing – original draft

  Affiliation CSIR Biosciences, Pretoria, South Africa

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• R. L. Roth,

  Roles Data curation, Investigation, Supervision, Writing – original draft

  Affiliation CSIR Biosciences, Pretoria, South Africa

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• H. Hoppe,

  Roles Data curation, Formal analysis, Investigation

  Current address: Dept of Biochemistry, Microbiology and Biotechnology, Rhodes University, Grahamstown, South Africa

  Affiliation CSIR Biosciences, Pretoria, South Africa

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• C. Parkinson,

  Roles Data curation, Formal analysis, Investigation, Supervision

  Affiliation School of Biomedical Sciences, Charles Sturt University, Orange NSW, Australia

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• C. W. van der Westhuyzen,

  Roles Data curation, Formal analysis, Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliation CSIR Biosciences, Pretoria, South Africa

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• S. Stoychev,

  Roles Data curation, Formal analysis

  Affiliation CSIR Biosciences, Pretoria, South Africa

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• I. Wiid,

  Roles Conceptualization, Data curation, Writing – original draft, Writing – review & editing

  Affiliation DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa

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• R. D. Pietersen,

  Roles Data curation, Formal analysis

  Affiliation DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa

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• B. Baker,

  Roles Data curation, Formal analysis, Validation, Writing – original draft, Writing – review & editing

  Affiliation DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa

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• C. P. Kenyon

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: kenyon@sun.ac.za

  Affiliations CSIR Biosciences, Pretoria, South Africa, DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa

  http://orcid.org/0000-0003-1590-7230

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