Modulating lysosomal function through lysosome membrane permeabilization or autophagy suppression restores sensitivity to cisplatin in refractory non-small-cell lung cancer cells

Magdalena Circu; James Cardelli; Martin Barr; Kenneth O’Byrne; Glenn Mills; Hazem El-Osta

doi:10.1371/journal.pone.0184922

Loading metrics

Open Access

Peer-reviewed

Research Article

Modulating lysosomal function through lysosome membrane permeabilization or autophagy suppression restores sensitivity to cisplatin in refractory non-small-cell lung cancer cells

Magdalena Circu,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, United States of America
⨯
James Cardelli,

Roles Software, Supervision, Writing – review & editing

Affiliation Segue Therapeutics, LLC, Shreveport, Louisiana, United States of America
⨯
Martin Barr,

Roles Resources, Writing – review & editing

Affiliation Thoracic Oncology Research Group, Trinity Translational Medicine Institute, Trinity Centre for Health Sciences, St. James’s Hospital & Trinity College Dublin, Dublin, Ireland
⨯
Kenneth O’Byrne,

Roles Resources, Writing – review & editing

Affiliation Cancer & Ageing Research Program, Queensland University of Technology, Brisbane, Australia
⨯
Glenn Mills,

Roles Funding acquisition, Resources, Writing – review & editing

Affiliation Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, United States of America
⨯
Hazem El-Osta

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: hazemelosta@yahoo.com, hazem.elosta@uth.tmc.edu

Current address: University of Texas Health Science Center, Houston, Texas, United States of America

Affiliation Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, United States of America

http://orcid.org/0000-0003-1825-2815

⨯

Modulating lysosomal function through lysosome membrane permeabilization or autophagy suppression restores sensitivity to cisplatin in refractory non-small-cell lung cancer cells

Magdalena Circu,
James Cardelli,
Martin Barr,
Kenneth O’Byrne,
Glenn Mills,
Hazem El-Osta

Published: September 25, 2017
https://doi.org/10.1371/journal.pone.0184922

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Chloroquine
Is the Subject Area "Chloroquine" applicable to this article?

Thanks for your feedback.
Lysosomes
Is the Subject Area "Lysosomes" applicable to this article?

Thanks for your feedback.
Autophagic cell death
Is the Subject Area "Autophagic cell death" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Lung and intrathoracic tumors
Is the Subject Area "Lung and intrathoracic tumors" applicable to this article?

Thanks for your feedback.
Non-small cell lung cancer
Is the Subject Area "Non-small cell lung cancer" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Drug therapy
Is the Subject Area "Drug therapy" applicable to this article?

Thanks for your feedback.