Simultaneous determination of 3-hydroxypropionic acid, methylmalonic acid and methylcitric acid in dried blood spots: Second-tier LC-MS/MS assay for newborn screening of propionic acidemia, methylmalonic acidemias and combined remethylation disorders

• Péter Monostori ,

  Contributed equally to this work with: Péter Monostori, Glynis Klinke, Gwendolyn Gramer, Jürgen G. Okun

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  * E-mail: monostoripeter@gmail.com

  Affiliation Department of General Pediatrics, Division of Neuropediatrics and Metabolic Medicine, Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany

  http://orcid.org/0000-0003-3591-6054

  ⨯
• Glynis Klinke ,

  Contributed equally to this work with: Péter Monostori, Glynis Klinke, Gwendolyn Gramer, Jürgen G. Okun

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliation Department of General Pediatrics, Division of Neuropediatrics and Metabolic Medicine, Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany

  ⨯
• Sylvia Richter,

  Roles Data curation, Investigation, Methodology, Validation, Writing – original draft

  Affiliation Department of General Pediatrics, Division of Neuropediatrics and Metabolic Medicine, Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany

  ⨯
• Ákos Baráth,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Department of Pediatrics, University of Szeged, Szeged, Hungary

  ⨯
• Ralph Fingerhut,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Children’s Research Center, Division of Metabolism, University Children’s Hospital Zurich, Zurich, Switzerland

  ⨯
• Matthias R. Baumgartner,

  Roles Supervision, Writing – review & editing

  Affiliation Children’s Research Center, Division of Metabolism, University Children’s Hospital Zurich, Zurich, Switzerland

  ⨯
• Stefan Kölker,

  Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

  Affiliation Department of General Pediatrics, Division of Neuropediatrics and Metabolic Medicine, Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany

  ⨯
• Georg F. Hoffmann,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Department of General Pediatrics, Division of Neuropediatrics and Metabolic Medicine, Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany

  ⨯
• Gwendolyn Gramer ,

  Contributed equally to this work with: Péter Monostori, Glynis Klinke, Gwendolyn Gramer, Jürgen G. Okun

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Supervision, Validation, Writing – original draft

  Affiliation Department of General Pediatrics, Division of Neuropediatrics and Metabolic Medicine, Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany

  ⨯
• Jürgen G. Okun

  Contributed equally to this work with: Péter Monostori, Glynis Klinke, Gwendolyn Gramer, Jürgen G. Okun

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft

  Affiliation Department of General Pediatrics, Division of Neuropediatrics and Metabolic Medicine, Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany

  ⨯