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Open Access
Peer-reviewed
Research Article
Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay
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Justin Hall ,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing
* E-mail: justin.hall@pfizer.com
Affiliation Medicine Design, Pfizer, Groton, Connecticut, United States of America
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Amy Brault,
Roles Formal analysis, Investigation
Affiliation Medicine Design, Pfizer, Groton, Connecticut, United States of America
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Fabien Vincent,
Roles Conceptualization, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing
Affiliation Medicine Design, Pfizer, Groton, Connecticut, United States of America
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Shawn Weng,
Roles Formal analysis, Investigation
Affiliation Pfizer Centers for Therapeutic Innovation (CTI), Boston, Massachusetts, United States of America
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Hong Wang,
Roles Formal analysis, Investigation
Affiliation Medicine Design, Pfizer, Groton, Connecticut, United States of America
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Darren Dumlao,
Roles Formal analysis, Investigation
Affiliation Medicine Design, Pfizer, Groton, Connecticut, United States of America
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Ann Aulabaugh,
Roles Supervision
Affiliation Medicine Design, Pfizer, Groton, Connecticut, United States of America
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Dikran Aivazian,
Roles Supervision
Affiliation Pfizer Centers for Therapeutic Innovation (CTI), San Diego, California, United States of America
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Dana Castro,
Roles Supervision
Affiliation Pfizer Centers for Therapeutic Innovation (CTI), San Diego, California, United States of America
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Ming Chen,
Roles Investigation
Affiliation Medicine Design, Pfizer, Groton, Connecticut, United States of America
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Jeffrey Culp,
Roles Supervision
Affiliation Medicine Design, Pfizer, Groton, Connecticut, United States of America
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Ken Dower,
Roles Formal analysis, Investigation, Methodology
Affiliation Inflammation and Immunology, Pfizer, Cambridge, Massachusetts, United States of America
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Joseph Gardner,
Roles Supervision
Affiliation External Research Solutions, Pfizer, Groton, Connecticut, United States of America
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Steven Hawrylik,
Roles Formal analysis, Investigation, Supervision
Affiliation Medicine Design, Pfizer, Groton, Connecticut, United States of America
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Douglas Golenbock,
Roles Supervision
Affiliation University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
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David Hepworth,
Roles Conceptualization, Supervision
Affiliation Medicine Design, Pfizer, Cambridge, Massachusetts, United States of America
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Mark Horn,
Roles Formal analysis, Investigation
Affiliation Pfizer Centers for Therapeutic Innovation (CTI), San Diego, California, United States of America
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Lyn Jones,
Roles Conceptualization, Supervision
Affiliation Medicine Design, Pfizer, Cambridge, Massachusetts, United States of America
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Peter Jones,
Roles Supervision
Affiliation Medicine Design, Pfizer, Cambridge, Massachusetts, United States of America
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Eicke Latz,
Roles Supervision
Affiliations University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Institute of Innate Immunity, University Hospitals Bonn, Bonn, Germany
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Jing Li,
Roles Investigation
Affiliation Medicine Design, Pfizer, Cambridge, Massachusetts, United States of America
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Lih-Ling Lin,
Roles Supervision
Affiliation Inflammation and Immunology, Pfizer, Cambridge, Massachusetts, United States of America
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Wen Lin,
Roles Investigation
Affiliation Medicine Design, Pfizer, Groton, Connecticut, United States of America
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David Lin,
Roles Investigation
Affiliation Medicine Design, Pfizer, Groton, Connecticut, United States of America
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Frank Lovering,
Roles Investigation
Affiliation Medicine Design, Pfizer, Cambridge, Massachusetts, United States of America
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Nootaree Niljanskul,
Roles Investigation
Affiliation Medicine Design, Pfizer, Groton, Connecticut, United States of America
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Ryan Nistler,
Roles Investigation
Affiliation Pfizer Centers for Therapeutic Innovation (CTI), Boston, Massachusetts, United States of America
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Betsy Pierce,
Roles Investigation
Affiliation Medicine Design, Pfizer, Groton, Connecticut, United States of America
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Olga Plotnikova,
Roles Investigation
Affiliation Medicine Design, Pfizer, Groton, Connecticut, United States of America
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Daniel Schmitt,
Roles Investigation
Affiliation Medicine Design, Pfizer, Groton, Connecticut, United States of America
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Suman Shanker,
Roles Investigation
Affiliation Medicine Design, Pfizer, Groton, Connecticut, United States of America
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James Smith,
Roles Investigation
Affiliation Medicine Design, Pfizer, Groton, Connecticut, United States of America
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William Snyder,
Roles Supervision
Affiliation Pfizer Centers for Therapeutic Innovation (CTI), San Diego, California, United States of America
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Timothy Subashi,
Roles Investigation
Affiliation Medicine Design, Pfizer, Groton, Connecticut, United States of America
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John Trujillo,
Roles Investigation
Affiliation Medicine Design, Pfizer, Groton, Connecticut, United States of America
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Edyta Tyminski,
Roles Investigation
Affiliation Pfizer Centers for Therapeutic Innovation (CTI), Boston, Massachusetts, United States of America
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Guoxing Wang,
Roles Investigation
Affiliation Pfizer Centers for Therapeutic Innovation (CTI), Boston, Massachusetts, United States of America
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Jimson Wong,
Roles Investigation
Affiliation Medicine Design, Pfizer, Groton, Connecticut, United States of America
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Bruce Lefker,
Roles Supervision
Affiliation Medicine Design, Pfizer, Cambridge, Massachusetts, United States of America
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Leslie Dakin,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing
Affiliation Medicine Design, Pfizer, Cambridge, Massachusetts, United States of America
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Karen Leach
Roles Conceptualization, Data curation, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing
Affiliation Pfizer Centers for Therapeutic Innovation (CTI), Boston, Massachusetts, United States of America
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Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay
- Justin Hall,
- Amy Brault,
- Fabien Vincent,
- Shawn Weng,
- Hong Wang,
- Darren Dumlao,
- Ann Aulabaugh,
- Dikran Aivazian,
- Dana Castro,
- Ming Chen
- Published: September 21, 2017
- https://doi.org/10.1371/journal.pone.0184843