Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation

Mengling Liu; Christopher J. Clarke; Mohamed F. Salama; Yeon Ja Choi; Lina M. Obeid; Yusuf A. Hannun

doi:10.1371/journal.pone.0184818

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Peer-reviewed

Research Article

Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation

Mengling Liu,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliations Department of Medicine, Stony Brook University, Stony Brook, NY, United States of America, Stony Brook Cancer Center, Stony Brook University Hospital, Stony Brook, NY, United States of America
⨯
Christopher J. Clarke,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliations Department of Medicine, Stony Brook University, Stony Brook, NY, United States of America, Stony Brook Cancer Center, Stony Brook University Hospital, Stony Brook, NY, United States of America
⨯
Mohamed F. Salama,

Roles Conceptualization, Formal analysis, Investigation

Affiliations Department of Medicine, Stony Brook University, Stony Brook, NY, United States of America, Department of Biochemistry, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt
⨯
Yeon Ja Choi,

Roles Formal analysis, Writing – original draft, Writing – review & editing

Affiliations Stony Brook Cancer Center, Stony Brook University Hospital, Stony Brook, NY, United States of America, Department of Pathology, Stony Brook University, Stony Brook, NY, United States of America
⨯
Lina M. Obeid,

Roles Conceptualization

Affiliations Department of Medicine, Stony Brook University, Stony Brook, NY, United States of America, Stony Brook Cancer Center, Stony Brook University Hospital, Stony Brook, NY, United States of America
⨯
Yusuf A. Hannun

Roles Conceptualization, Writing – original draft, Writing – review & editing

* E-mail: yusuf.hannun@stonybrookmedicine.edu

Affiliations Department of Medicine, Stony Brook University, Stony Brook, NY, United States of America, Stony Brook Cancer Center, Stony Brook University Hospital, Stony Brook, NY, United States of America, Department of Pathology, Stony Brook University, Stony Brook, NY, United States of America

http://orcid.org/0000-0003-3349-3369

⨯

Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation

Mengling Liu,
Christopher J. Clarke,
Mohamed F. Salama,
Yeon Ja Choi,
Lina M. Obeid,
Yusuf A. Hannun

Published: September 19, 2017
https://doi.org/10.1371/journal.pone.0184818

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