HLA-DR7 and HLA-DQ2: Transgenic mouse strains tested as a model system for ximelagatran hepatotoxicity

Hanna Lundgren; Klara Martinsson; Karin Cederbrant; Johan Jirholt; Daniel Mucs; Katja Madeyski-Bengtson; Said Havarinasab; Per Hultman

doi:10.1371/journal.pone.0184744

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Open Access

Peer-reviewed

Research Article

HLA-DR7 and HLA-DQ2: Transgenic mouse strains tested as a model system for ximelagatran hepatotoxicity

Hanna Lundgren,

Roles Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft

Affiliation Division of Molecular and Immunological Pathology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Östergötland County Council, Linköping, Sweden
⨯
Klara Martinsson,

Roles Formal analysis, Investigation, Methodology, Validation

Affiliation AIR/Rheumatology Unit, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Östergötland County Council, Linköping, Sweden
⨯
Karin Cederbrant ,

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – review & editing

* E-mail: Karin.Cederbrant@swetox.se

Affiliations Division of Molecular and Immunological Pathology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Östergötland County Council, Linköping, Sweden, Swetox, Karolinska Institutet, Unit of Toxicology Sciences, Södertälje, Sweden
⨯
Johan Jirholt,

Roles Conceptualization, Methodology, Resources

Affiliation AstraZeneca R&D, Transgenic center, Mölndal, Sweden
⨯
Daniel Mucs,

Roles Methodology, Validation, Visualization

Affiliation Swetox, Karolinska Institutet, Unit of Toxicology Sciences, Södertälje, Sweden
⨯
Katja Madeyski-Bengtson,

Roles Formal analysis

Affiliation AstraZeneca R&D, Transgenic center, Mölndal, Sweden
⨯
Said Havarinasab,

Roles Formal analysis

Affiliation Division of Molecular and Immunological Pathology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Östergötland County Council, Linköping, Sweden
⨯
Per Hultman

Roles Supervision, Writing – review & editing

Affiliation Division of Molecular and Immunological Pathology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Östergötland County Council, Linköping, Sweden
⨯

HLA-DR7 and HLA-DQ2: Transgenic mouse strains tested as a model system for ximelagatran hepatotoxicity

Hanna Lundgren,
Klara Martinsson,
Karin Cederbrant,
Johan Jirholt,
Daniel Mucs,
Katja Madeyski-Bengtson,
Said Havarinasab,
Per Hultman

Published: September 21, 2017
https://doi.org/10.1371/journal.pone.0184744

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