Oxidative stress induces dysregulated autophagy in corneal epithelium of keratoconus patients

Rohit Shetty; Anupam Sharma; Natasha Pahuja; Priyanka Chevour; Neeraja Padmajan; Kamesh Dhamodaran; Chaitra Jayadev; Rudy M. M. A. Nuijts; Arkasubhra Ghosh; Jeyabalan Nallathambi

doi:10.1371/journal.pone.0184628

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Open Access

Peer-reviewed

Research Article

Oxidative stress induces dysregulated autophagy in corneal epithelium of keratoconus patients

Rohit Shetty ,

Contributed equally to this work with: Rohit Shetty, Anupam Sharma, Natasha Pahuja

Roles Data curation, Resources, Validation

Affiliation Department of Cornea and Refractive surgery, Narayana Nethralaya Eye Hospital, Narayana Health City, Bommasandra, Bangalore, Karnataka, India
⨯
Anupam Sharma ,

Contributed equally to this work with: Rohit Shetty, Anupam Sharma, Natasha Pahuja

Roles Data curation, Methodology, Software, Validation

Affiliation GROW Research Laboratory, Narayana Nethralaya Foundation, Bangalore, Karnataka, India
⨯
Natasha Pahuja ,

Contributed equally to this work with: Rohit Shetty, Anupam Sharma, Natasha Pahuja

Roles Formal analysis, Methodology, Resources

Affiliation Department of Cornea and Refractive surgery, Narayana Nethralaya Eye Hospital, Narayana Health City, Bommasandra, Bangalore, Karnataka, India
⨯
Priyanka Chevour,

Roles Data curation, Formal analysis, Methodology, Resources

Affiliation GROW Research Laboratory, Narayana Nethralaya Foundation, Bangalore, Karnataka, India
⨯
Neeraja Padmajan,

Roles Formal analysis, Investigation, Methodology

Affiliation GROW Research Laboratory, Narayana Nethralaya Foundation, Bangalore, Karnataka, India
⨯
Kamesh Dhamodaran,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation GROW Research Laboratory, Narayana Nethralaya Foundation, Bangalore, Karnataka, India
⨯
Chaitra Jayadev,

Roles Data curation, Formal analysis, Methodology, Resources, Validation, Visualization

Affiliation Department of Cornea and Refractive surgery, Narayana Nethralaya Eye Hospital, Narayana Health City, Bommasandra, Bangalore, Karnataka, India
⨯
Rudy M. M. A. Nuijts,

Roles Data curation, Formal analysis, Methodology, Project administration, Resources

Affiliation Maastricht University Medical Centre, Maastricht, The Netherlands
⨯
Arkasubhra Ghosh ,

Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

* E-mail: drnallathambi@narayananethralaya.com (JN); arkasubhra@narayananethralaya.com (AG)

Affiliation GROW Research Laboratory, Narayana Nethralaya Foundation, Bangalore, Karnataka, India
⨯
Jeyabalan Nallathambi

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

* E-mail: drnallathambi@narayananethralaya.com (JN); arkasubhra@narayananethralaya.com (AG)

Affiliation GROW Research Laboratory, Narayana Nethralaya Foundation, Bangalore, Karnataka, India

http://orcid.org/0000-0001-7380-8762

⨯

Oxidative stress induces dysregulated autophagy in corneal epithelium of keratoconus patients

Rohit Shetty,
Anupam Sharma,
Natasha Pahuja,
Priyanka Chevour,
Neeraja Padmajan,
Kamesh Dhamodaran,
Chaitra Jayadev,
Rudy M. M. A. Nuijts,
Arkasubhra Ghosh,
Jeyabalan Nallathambi

Published: September 13, 2017
https://doi.org/10.1371/journal.pone.0184628

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Cornea
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Autophagic cell death
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Oxidative stress
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Oxidative damage
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