Enhancing monellin production by Pichia pastoris at low cell induction concentration via effectively regulating methanol metabolism patterns and energy utilization efficiency

Luqiang Jia; Tingyong Tu; Qiangqiang Huai; Jiaowen Sun; Shanshan Chen; Xin Li; Zhongping Shi; Jian Ding

doi:10.1371/journal.pone.0184602

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Open Access

Peer-reviewed

Research Article

Enhancing monellin production by Pichia pastoris at low cell induction concentration via effectively regulating methanol metabolism patterns and energy utilization efficiency

Luqiang Jia,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

Affiliation The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China
⨯
Tingyong Tu,

Roles Data curation, Investigation, Validation

Affiliation The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China
⨯
Qiangqiang Huai,

Roles Data curation, Investigation, Validation

Affiliation The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China
⨯
Jiaowen Sun,

Roles Data curation, Investigation

Affiliation The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China
⨯
Shanshan Chen,

Roles Data curation, Investigation

Affiliation The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China
⨯
Xin Li,

Roles Resources

Affiliation School of Biology and Pharmaceutical engineering, Wuhan Polytechnic University, Wuhan, Hubei, China
⨯
Zhongping Shi ,

Roles Conceptualization, Formal analysis, Methodology, Project administration, Supervision, Writing – review & editing

* E-mail: zpshi@jiangnan.edu.cn (ZS); dingjian@jiangnan.edu.cn (JD)

Affiliation The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China

http://orcid.org/0000-0001-5558-9586

⨯
Jian Ding

Roles Funding acquisition, Supervision

* E-mail: zpshi@jiangnan.edu.cn (ZS); dingjian@jiangnan.edu.cn (JD)

Affiliation The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China
⨯

Enhancing monellin production by Pichia pastoris at low cell induction concentration via effectively regulating methanol metabolism patterns and energy utilization efficiency

Luqiang Jia,
Tingyong Tu,
Qiangqiang Huai,
Jiaowen Sun,
Shanshan Chen,
Xin Li,
Zhongping Shi,
Jian Ding

Published: October 5, 2017
https://doi.org/10.1371/journal.pone.0184602

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Fermentation
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Cell growth
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Energy metabolism
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Protein synthesis
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Glycerol
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