Application of a whole blood mycobacterial growth inhibition assay to study immunity against Mycobacterium tuberculosis in a high tuberculosis burden population

• Richard Baguma ,

  Contributed equally to this work with: Richard Baguma, Adam Penn-Nicholson

  Roles Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

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• Adam Penn-Nicholson ,

  Contributed equally to this work with: Richard Baguma, Adam Penn-Nicholson

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: adam.penn-nicholson@uct.ac.za

  Affiliation South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

  http://orcid.org/0000-0002-1883-0059

  ⨯
• Erica Smit,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

  ⨯
• Mzwandile Erasmus,

  Roles Investigation, Methodology

  Affiliation South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

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• Jonathan Day,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology

  Affiliation South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

  ⨯
• Lebohang Makhethe,

  Roles Investigation, Methodology

  Affiliation South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

  ⨯
• Marwou de Kock,

  Roles Investigation

  Affiliation South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

  ⨯
• E. Jane Hughes,

  Roles Investigation

  Affiliation South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

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• Michele van Rooyen,

  Roles Investigation

  Affiliation South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

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• Bernadette Pienaar †,

  † Deceased.

  Roles Investigation

  Affiliation South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

  ⨯
• Lynnett Stone,

  Roles Investigation

  Affiliation South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

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• Willem Hanekom,

  Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – review & editing

  Affiliation South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

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• Michael J. Brennan,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation Aeras, Rockville, Maryland, United States of America

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• Robert S. Wallis,

  Roles Conceptualization, Formal analysis, Software, Writing – review & editing

  Affiliation The Aurum Institute, Johannesburg, South Africa

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• Mark Hatherill,

  Roles Formal analysis, Methodology, Supervision, Writing – review & editing

  Affiliation South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

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•  [ ... ],
• Thomas J. Scriba

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Supervision, Writing – review & editing

  Affiliation South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

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