PD-1 and CTLA-4 up regulation on donor T cells is insufficient to prevent GvHD in allo-HSCT recipients

Mohammad S. Hossain; Ghada M. Kunter; Vicky F. El-Najjar; David L. Jaye; Zaid Al-Kadhimi; Owonikoko K. Taofeek; Jian-Ming Li; Edmund K. Waller

doi:10.1371/journal.pone.0184254

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Open Access

Peer-reviewed

Research Article

PD-1 and CTLA-4 up regulation on donor T cells is insufficient to prevent GvHD in allo-HSCT recipients

Mohammad S. Hossain,

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Department of Hematology and Medical Oncology, Division of Stem Cell and Bone Marrow Transplantation, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Ghada M. Kunter,

Roles Investigation

Affiliation Holzer Cancer Center, Gallipolis, Ohio, United States of America
⨯
Vicky F. El-Najjar,

Roles Investigation

Affiliation Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
David L. Jaye,

Roles Formal analysis, Investigation

Affiliation Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Zaid Al-Kadhimi,

Roles Investigation

Affiliation Department of Hematology and Medical Oncology, Division of Stem Cell and Bone Marrow Transplantation, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Owonikoko K. Taofeek,

Roles Investigation

Affiliation Department of Hematology and Medical Oncology, Division of Stem Cell and Bone Marrow Transplantation, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Jian-Ming Li,

Roles Investigation, Visualization, Writing – review & editing

Affiliation Department of Hematology and Medical Oncology, Division of Stem Cell and Bone Marrow Transplantation, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Edmund K. Waller

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Supervision, Visualization, Writing – review & editing

* E-mail: ewaller@emory.edu

Affiliation Department of Hematology and Medical Oncology, Division of Stem Cell and Bone Marrow Transplantation, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, United States of America

http://orcid.org/0000-0003-0816-6729

⨯

PD-1 and CTLA-4 up regulation on donor T cells is insufficient to prevent GvHD in allo-HSCT recipients

Mohammad S. Hossain,
Ghada M. Kunter,
Vicky F. El-Najjar,
David L. Jaye,
Zaid Al-Kadhimi,
Owonikoko K. Taofeek,
Jian-Ming Li,
Edmund K. Waller

Published: September 27, 2017
https://doi.org/10.1371/journal.pone.0184254

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