CPVT-associated cardiac ryanodine receptor mutation G357S with reduced penetrance impairs Ca2+ release termination and diminishes protein expression

Yingjie Liu; Jinhong Wei; Siobhan M. Wong King Yuen; Bo Sun; Yijun Tang; Ruiwu Wang; Filip Van Petegem; S. R. Wayne Chen

doi:10.1371/journal.pone.0184177

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Open Access

Peer-reviewed

Research Article

CPVT-associated cardiac ryanodine receptor mutation G357S with reduced penetrance impairs Ca²⁺ release termination and diminishes protein expression

Yingjie Liu,

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
⨯
Jinhong Wei,

Roles Conceptualization, Data curation, Formal analysis, Investigation

Affiliation Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
⨯
Siobhan M. Wong King Yuen,

Roles Conceptualization, Data curation, Formal analysis

Affiliation Department of Biochemistry and Molecular Biology, University of British Columbia, 2350 Health Sciences Mall, Vancouver, Canada
⨯
Bo Sun,

Roles Conceptualization, Data curation, Formal analysis

Affiliation Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
⨯
Yijun Tang,

Roles Conceptualization, Data curation, Formal analysis

Current address: Taihe Hospital Affiliated Hospital of Hubei University of Medicine, Hubei, P.R., China.

Affiliation Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
⨯
Ruiwu Wang,

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft

Affiliation Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
⨯
Filip Van Petegem,

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

Affiliation Department of Biochemistry and Molecular Biology, University of British Columbia, 2350 Health Sciences Mall, Vancouver, Canada
⨯
S. R. Wayne Chen

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: swchen@ucalgary.ca

Affiliation Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada

http://orcid.org/0000-0001-5808-0304

⨯

CPVT-associated cardiac ryanodine receptor mutation G357S with reduced penetrance impairs Ca²⁺ release termination and diminishes protein expression

Yingjie Liu,
Jinhong Wei,
Siobhan M. Wong King Yuen,
Bo Sun,
Yijun Tang,
Ruiwu Wang,
Filip Van Petegem,
S. R. Wayne Chen

Published: September 29, 2017
https://doi.org/10.1371/journal.pone.0184177

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Fluorescence resonance energy transfer
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Cell binding
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Protein expression
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Point mutation
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Caffeine
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Fluorescence imaging
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Endoplasmic reticulum
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Transfection
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