Efficacy and safety of intravenous laronidase for mucopolysaccharidosis type I: A systematic review and meta-analysis

• Alícia Dorneles Dornelles ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: alidorneles@gmail.com

  Affiliation Postgraduate Program in Genetics Applied to Medicine, Department of Pediatrics, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

  http://orcid.org/0000-0002-8140-6496

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• Osvaldo Artigalás,

  Roles Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Hospital Materno-Infantil Presidente Vargas, Porto Alegre, RS, Brazil, Clinical Genetics Unit, Children's Hospital, Grupo Hospitalar Conceição, Porto Alegre, RS, Brazil

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• André Anjos da Silva,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation UNIVATES University, Lajeado, RS, Brazil

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• Dora Lucia Vallejo Ardila,

  Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Genetics, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

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• Taciane Alegra,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Nutrition, Biomarkers and Health Research Group, University College Dublin, Dublin, Ireland

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• Tiago Veiga Pereira,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Instituto de Educação e Ciências em Saúde, Hospital Alemão Osvaldo Cruz, São Paulo, SP, Brazil

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• Filippo Pinto e Vairo,

  Roles Conceptualization, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Medical Genetics Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil

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• Ida Vanessa Doederlein Schwartz

  Roles Conceptualization, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Postgraduate Program in Genetics Applied to Medicine, Department of Pediatrics, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil, Department of Genetics, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil, Medical Genetics Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil, BRAIN Laboratory, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil

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