Oxygen environment and islet size are the primary limiting factors of isolated pancreatic islet survival

Hirotake Komatsu; Colin Cook; Chia-Hao Wang; Leonard Medrano; Henry Lin; Fouad Kandeel; Yu-Chong Tai; Yoko Mullen

doi:10.1371/journal.pone.0183780

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Open Access

Peer-reviewed

Research Article

Oxygen environment and islet size are the primary limiting factors of isolated pancreatic islet survival

Hirotake Komatsu ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

* E-mail: hkomatsu@coh.org

Affiliation Division of Developmental and Translational Diabetes and Endocrinology Research, Department of Diabetes and Metabolic Researches, Beckman Research Institute of City of Hope, Duarte, California, United States of America
⨯
Colin Cook,

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization

Affiliation Department of Electrical Engineering, California Institute of Technology, Pasadena, California, United States of America
⨯
Chia-Hao Wang,

Roles Data curation, Formal analysis, Methodology, Visualization

Affiliation Division of Developmental and Translational Diabetes and Endocrinology Research, Department of Diabetes and Metabolic Researches, Beckman Research Institute of City of Hope, Duarte, California, United States of America
⨯
Leonard Medrano,

Roles Data curation, Investigation

Affiliation Division of Developmental and Translational Diabetes and Endocrinology Research, Department of Diabetes and Metabolic Researches, Beckman Research Institute of City of Hope, Duarte, California, United States of America
⨯
Henry Lin,

Roles Project administration, Resources

Affiliation Division of Developmental and Translational Diabetes and Endocrinology Research, Department of Diabetes and Metabolic Researches, Beckman Research Institute of City of Hope, Duarte, California, United States of America
⨯
Fouad Kandeel,

Roles Supervision

Affiliation Division of Developmental and Translational Diabetes and Endocrinology Research, Department of Diabetes and Metabolic Researches, Beckman Research Institute of City of Hope, Duarte, California, United States of America
⨯
Yu-Chong Tai,

Roles Supervision

Affiliation Department of Electrical Engineering, California Institute of Technology, Pasadena, California, United States of America
⨯
Yoko Mullen

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliation Division of Developmental and Translational Diabetes and Endocrinology Research, Department of Diabetes and Metabolic Researches, Beckman Research Institute of City of Hope, Duarte, California, United States of America
⨯

Oxygen environment and islet size are the primary limiting factors of isolated pancreatic islet survival

Hirotake Komatsu,
Colin Cook,
Chia-Hao Wang,
Leonard Medrano,
Henry Lin,
Fouad Kandeel,
Yu-Chong Tai,
Yoko Mullen

Published: August 23, 2017
https://doi.org/10.1371/journal.pone.0183780

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Oxygen
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Islet transplantation
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Necrosis
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Medical hypoxia
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Hypoxia
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Liver transplantation
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Cell viability testing
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Pancreas
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