Resveratrol and caloric restriction prevent hepatic steatosis by regulating SIRT1-autophagy pathway and alleviating endoplasmic reticulum stress in high-fat diet-fed rats

Shibin Ding; Jinjin Jiang; Guofu Zhang; Yongjun Bu; Guanghui Zhang; Xiangmei Zhao

doi:10.1371/journal.pone.0183541

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Open Access

Peer-reviewed

Research Article

Resveratrol and caloric restriction prevent hepatic steatosis by regulating SIRT1-autophagy pathway and alleviating endoplasmic reticulum stress in high-fat diet-fed rats

Shibin Ding ,

Contributed equally to this work with: Shibin Ding, Jinjin Jiang

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Software, Writing – original draft, Writing – review & editing

* E-mail: dingshibin@163.com.

Current address: Department of Nutrition and Food Hygiene, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, PR China

Affiliations Department of Nutrition and Food Hygiene, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, PR China, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan Province, PR China

http://orcid.org/0000-0003-1341-3595

⨯
Jinjin Jiang ,

Contributed equally to this work with: Shibin Ding, Jinjin Jiang

Roles Formal analysis, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

Affiliation School of Public Health, Capital Medical University, Beijing, PR China
⨯
Guofu Zhang,

Roles Formal analysis, Methodology, Project administration

Affiliation Department of Nutrition and Food Hygiene, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, PR China
⨯
Yongjun Bu,

Roles Data curation, Formal analysis, Methodology

Affiliation Department of Nutrition and Food Hygiene, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, PR China
⨯
Guanghui Zhang,

Roles Investigation, Methodology

Affiliation Department of Nutrition and Food Hygiene, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, PR China
⨯
Xiangmei Zhao

Roles Data curation, Formal analysis, Software

Affiliation Department of Nutrition and Food Hygiene, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, PR China
⨯

Resveratrol and caloric restriction prevent hepatic steatosis by regulating SIRT1-autophagy pathway and alleviating endoplasmic reticulum stress in high-fat diet-fed rats

Shibin Ding,
Jinjin Jiang,
Guofu Zhang,
Yongjun Bu,
Guanghui Zhang,
Xiangmei Zhao

Published: August 17, 2017
https://doi.org/10.1371/journal.pone.0183541

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