Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity

• Chun-Che Tseng ,

  Contributed equally to this work with: Chun-Che Tseng, Bailing Jia

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology Georgetown University, Washington DC, United States of America

  ⨯
• Bailing Jia ,

  Contributed equally to this work with: Chun-Che Tseng, Bailing Jia

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

  Affiliations Lombardi Comprehensive Cancer Center, Department of Oncology Georgetown University, Washington DC, United States of America, Department of Gastroenterology, Henan Provincial People’s Hospital, Zhengzhou, China

  ⨯
• Robert Barndt,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization

  Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology Georgetown University, Washington DC, United States of America

  ⨯
• Yayun Gu,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology Georgetown University, Washington DC, United States of America

  ⨯
• Chien-Yu Chen,

  Roles Data curation, Investigation

  Affiliations Department of Biochemistry National Defense Medical Center, Taipei, Taiwan, School of Medicine National Defense Medical Center, Taipei, Taiwan

  ⨯
• I-Chu Tseng,

  Roles Data curation, Investigation

  Current address: Del E. Webb Neuroscience, Aging & Stem Cell Research Center Sanford-Burnham-Prebys Medical Discovery Institute 10901 North Torrey Pines Road, La Jolla, California, United States of America

  Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology Georgetown University, Washington DC, United States of America

  ⨯
• Sheng-Fang Su,

  Roles Data curation, Investigation

  Current address: Center of Biotechnology National Taiwan University, No1, Sec4, Roosevelt Rd, Taipei 10617, Taiwan

  Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology Georgetown University, Washington DC, United States of America

  ⨯
• Jehng-Kang Wang,

  Roles Funding acquisition, Investigation, Project administration, Supervision

  Affiliation Department of Biochemistry National Defense Medical Center, Taipei, Taiwan

  ⨯
• Michael D. Johnson ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: lincy@georgetown.edu (CYL); johnsom@georgetown.edu (MDJ)

  Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology Georgetown University, Washington DC, United States of America

  ⨯
• Chen-Yong Lin

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: lincy@georgetown.edu (CYL); johnsom@georgetown.edu (MDJ)

  Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology Georgetown University, Washington DC, United States of America

  http://orcid.org/0000-0002-6391-2571

  ⨯