Bispecific T cell engager (BiTE®) antibody constructs can mediate bystander tumor cell killing

Sandra L. Ross; Marika Sherman; Patricia L. McElroy; Julie A. Lofgren; Gordon Moody; Patrick A. Baeuerle; Angela Coxon; Tara Arvedson

doi:10.1371/journal.pone.0183390

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Open Access

Peer-reviewed

Research Article

Bispecific T cell engager (BiTE^®) antibody constructs can mediate bystander tumor cell killing

Sandra L. Ross,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

Affiliation Department of Oncology Research, Amgen Inc., Thousand Oaks, California, United States of America
⨯
Marika Sherman,

Roles Investigation, Methodology, Visualization, Writing – review & editing

Current address: Department of Translational Sciences, Kite Pharma, Inc., Santa Monica, California, United States of America

Affiliation Department of Oncology Research, Amgen Inc., Thousand Oaks, California, United States of America
⨯
Patricia L. McElroy,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Oncology Research, Amgen Inc., Thousand Oaks, California, United States of America
⨯
Julie A. Lofgren,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Oncology Research, Amgen Inc., Thousand Oaks, California, United States of America
⨯
Gordon Moody,

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

Current address: Department of Oncology, Medimmune, Gaithersburg, Maryland, United States of America

Affiliation Department of Oncology Research, Amgen Inc., Thousand Oaks, California, United States of America
⨯
Patrick A. Baeuerle,

Roles Formal analysis, Writing – original draft, Writing – review & editing

Current address: MPM Capital, Cambridge, Massachusetts, United States of America

Affiliation Department of Amgen Research Munich, Amgen Inc., Munich, Germany
⨯
Angela Coxon,

Roles Supervision, Writing – review & editing

Affiliation Department of Oncology Research, Amgen Inc., Thousand Oaks, California, United States of America
⨯
Tara Arvedson

Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: taraa@amgen.com

Affiliation Department of Oncology Research, Amgen Inc., Thousand Oaks, California, United States of America

http://orcid.org/0000-0001-9375-3017

⨯

Bispecific T cell engager (BiTE^®) antibody constructs can mediate bystander tumor cell killing

Sandra L. Ross,
Marika Sherman,
Patricia L. McElroy,
Julie A. Lofgren,
Gordon Moody,
Patrick A. Baeuerle,
Angela Coxon,
Tara Arvedson

Published: August 24, 2017
https://doi.org/10.1371/journal.pone.0183390

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