Comparison of homologous and heterologous prime-boost vaccine approaches using Modified Vaccinia Ankara and soluble protein to induce neutralizing antibodies by the human cytomegalovirus pentamer complex in mice

Flavia Chiuppesi; Felix Wussow; Louise Scharf; Heidi Contreras; Han Gao; Zhuo Meng; Jenny Nguyen; Peter A. Barry; Pamela J. Bjorkman; Don J. Diamond

doi:10.1371/journal.pone.0183377

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Open Access

Peer-reviewed

Research Article

Comparison of homologous and heterologous prime-boost vaccine approaches using Modified Vaccinia Ankara and soluble protein to induce neutralizing antibodies by the human cytomegalovirus pentamer complex in mice

Flavia Chiuppesi,

Roles Investigation

Affiliation Department of Experimental Therapeutics, Beckman Research Institute of the City of Hope, Duarte, CA, United States of America
⨯
Felix Wussow,

Roles Investigation

Affiliation Department of Experimental Therapeutics, Beckman Research Institute of the City of Hope, Duarte, CA, United States of America
⨯
Louise Scharf,

Roles Investigation

Affiliation Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, United States of America
⨯
Heidi Contreras,

Roles Investigation

Affiliation Department of Experimental Therapeutics, Beckman Research Institute of the City of Hope, Duarte, CA, United States of America
⨯
Han Gao,

Roles Methodology

Affiliation Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, United States of America
⨯
Zhuo Meng,

Roles Methodology

Affiliation Department of Experimental Therapeutics, Beckman Research Institute of the City of Hope, Duarte, CA, United States of America
⨯
Jenny Nguyen,

Roles Methodology

Affiliation Department of Experimental Therapeutics, Beckman Research Institute of the City of Hope, Duarte, CA, United States of America
⨯
Peter A. Barry,

Roles Investigation

Affiliation Center for Comparative Medicine, California National Primate Research Center, Department of Pathology and Laboratory Medicine, University of California Davis, Davis, CA, United States of America
⨯
Pamela J. Bjorkman,

Roles Investigation

Affiliation Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, United States of America
⨯
Don J. Diamond

Roles Investigation

* E-mail: ddiamond@coh.org

Affiliation Department of Experimental Therapeutics, Beckman Research Institute of the City of Hope, Duarte, CA, United States of America

http://orcid.org/0000-0003-3579-7083

⨯

Comparison of homologous and heterologous prime-boost vaccine approaches using Modified Vaccinia Ankara and soluble protein to induce neutralizing antibodies by the human cytomegalovirus pentamer complex in mice

Flavia Chiuppesi,
Felix Wussow,
Louise Scharf,
Heidi Contreras,
Han Gao,
Zhuo Meng,
Jenny Nguyen,
Peter A. Barry,
Pamela J. Bjorkman,
Don J. Diamond

Published: August 16, 2017
https://doi.org/10.1371/journal.pone.0183377

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