Increased half-life and enhanced potency of Fc-modified human PCSK9 monoclonal antibodies in primates

Yijun Shen; Hua Li; Li Zhao; Gang Li; Ben Chen; Qingsong Guo; Bei Gao; Jinsong Wu; Tong Yang; Li Jin; Yong Su

doi:10.1371/journal.pone.0183326

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Open Access

Peer-reviewed

Research Article

Increased half-life and enhanced potency of Fc-modified human PCSK9 monoclonal antibodies in primates

Yijun Shen ,

Contributed equally to this work with: Yijun Shen, Hua Li

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

Affiliations Ministry of Education Key Laboratory of Contemporary Anthropology, Fudan University, Shanghai, China, R&D Department of Genetic Engineering, Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., Shanghai, China
⨯
Hua Li ,

Contributed equally to this work with: Yijun Shen, Hua Li

Roles Data curation, Writing – original draft

Affiliation R&D Department of Genetic Engineering, Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., Shanghai, China
⨯
Li Zhao,

Roles Formal analysis, Validation

Affiliation R&D Department of Genetic Engineering, Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., Shanghai, China
⨯
Gang Li,

Roles Conceptualization

Affiliation R&D Department of Genetic Engineering, Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., Shanghai, China
⨯
Ben Chen,

Roles Methodology, Validation

Affiliation R&D Department of Genetic Engineering, Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., Shanghai, China
⨯
Qingsong Guo,

Roles Investigation

Affiliation R&D Department of Genetic Engineering, Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., Shanghai, China
⨯
Bei Gao,

Roles Investigation

Affiliation R&D Department of Genetic Engineering, Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., Shanghai, China
⨯
Jinsong Wu,

Roles Resources

Affiliation R&D Department of Genetic Engineering, Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., Shanghai, China
⨯
Tong Yang,

Roles Software

Affiliation R&D Department of Genetic Engineering, Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., Shanghai, China
⨯
Li Jin ,

Roles Writing – review & editing

* E-mail: lijin.fudan@gmail.com (LJ); ysu@fd-zj.com (YS)

Affiliation Ministry of Education Key Laboratory of Contemporary Anthropology, Fudan University, Shanghai, China
⨯
Yong Su

Roles Funding acquisition

* E-mail: lijin.fudan@gmail.com (LJ); ysu@fd-zj.com (YS)

Affiliation R&D Department of Genetic Engineering, Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., Shanghai, China

http://orcid.org/0000-0002-6206-1664

⨯

Increased half-life and enhanced potency of Fc-modified human PCSK9 monoclonal antibodies in primates

Yijun Shen,
Hua Li,
Li Zhao,
Gang Li,
Ben Chen,
Qingsong Guo,
Bei Gao,
Jinsong Wu,
Tong Yang,
Li Jin

Published: August 17, 2017
https://doi.org/10.1371/journal.pone.0183326

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